Search
immature colon carcinoma transcript 1 protein; peptidyl-tRNA hydrolase ICT1, mitochondrial; digestion substraction 1; DS-1 (ICT1, DS1)
Function:
- peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit
- codon-independent translation release factor that has lost all stop codon specificity & directs the termination of translation in mitochondrion, possibly in case of abortive elongation
- may be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated & thus in the recycling of stalled mitochondrial ribosomes
N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA component of the mitochondrial 39S ribosomal subunit
Structure:
- belongs to the prokaryotic/mitochondrial release factor family, ICT1 subfamily
- in contrast to other members of the family, lacks the regions that come into close contact with the mRNA in the ribosomal A-site & determine the STOP codon specificity, explaining the loss of codon specificity for translation release factor activity
Compartment: mitochondria
Expression:
- down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells
General
hydrolase
mitochondrial protein
phosphoprotein
Properties
SIZE: entity length = 206 aa
MW = 24 kD
COMPARTMENT: mitochondria
MOTIF: Thr phosphorylation site {T169}
Database Correlations
OMIM 603000
UniProt Q14197
Pfam PF00472
Entrez Gene 3396
Kegg hsa:3396
ENZYME 3.1.1.29
References
UniProt :accession Q14197