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interleukin-9 receptor (IL9 receptor, CD129)
Function: receptor for interleukin-9
Structure:
- the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 4 subfamily
- contains 1 fibronectin F3 module
Compartment:
- cell membrane
- secreted
Note:
- the gene encoding for this protein is located in the pseudoautosomal region 2 (PAR2) of X & Y chromosomes
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
hematopoietin receptor superfamily
interleukin receptor
Properties
SIZE: entity length = 521 aa
MW = 57 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-40}
N-glycosylation site {N117}
fibronectin type III domain or F3 module {150-244}
MOTIF: N-glycosylation site {N156}
WSXWS motif {245-249}
transmembrane domain {271-291}
box1 motif
SITE: 301-309
FOR-BINDING-OF: Janus kinase (JAK)
serine-rich region {429-438}
MOTIF: serine residue (SEVERAL)
Database Correlations
OMIM 300007
UniProt Q01113
Entrez Gene 3581
Kegg hsa:3581
References
- UniProt :accession Q01113
- SeattleSNPs
http://pga.gs.washington.edu/data/il9r/
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470