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CD127; CDw127; interleukin-7 [IL-7] receptor-alpha (IL7RA, IL7R)
Function:
- receptor for interleukin-7
- heterodimer of an alpha chain & a common gamma chain
Structure:
- WSXWS motif appears to be necessary for proper protein folding & thereby efficient intracellular transport & cell-surface receptor binding
- box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 4 subfamily
- contains 1 fibronectin F3 module
Compartment:
- isoforms H20, H1: cell membrane
- isoform H6, secreted
Alternative splicing: named isoforms=4 ;H20, H1, H6
Expression:
- diminished expression of IL7R associated with longevity [7]
Pathology:
- polymorphism(s) in IL7R (alpha) associated with risk of multiple sclerosis
Related
CD127 blasts in blood
CD127 blasts in bone marrow
interleukin-7 receptor (IL7 receptor)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
hematopoietin receptor superfamily
phosphoprotein
Properties
SIZE: MW = 52 kD
entity length = 459 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-20}
N-glycosylation site {N49}
N-glycosylation site {N65}
fibronectin type III domain or F3 module {128-224}
MOTIF: N-glycosylation site {N151}
N-glycosylation site {N182}
threonine-rich region {184-189}
MOTIF: threonine residue (SEVERAL)
WSXWS motif {217-221}
N-glycosylation site {N232}
N-glycosylation site {N233}
transmembrane domain {240-264}
box1 motif
SITE: 272-280
FOR-BINDING-OF: Janus kinase (JAK)
Thr phosphorylation site {T282}
Database Correlations
OMIM 146661
MORBIDMAP 146661
UniProt P16871
Entrez Gene 3575
References
- Krantz SB.
Erythropoietin.
Blood. 1991 Feb 1;77(3):419-34. Review.
PMID: 1991159
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- Ihle JN et al
Signaling by the cytokine receptor superfamily: JAKs and STATs
TIBS 19:222 1994
PMID: 8048164
- Entrez Gene :accession 3575
- GeneReviews;
https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL7R
- UniProt :accession P16871
- Passtoors WM
Transcriptional profiling of human familial longevity
indicates a role for ASF1A and IL7R.
PLoS One. 2012;7(1):e27759. Epub 2012 Jan 11.
PMID: 22247756
Component-of
interleukin-7 receptor (IL7 receptor)