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interleukin-7 receptor (IL7 receptor)
Related
interleukin-7; lymphopoietin-1 (IL7, IL-7)
General
interleukin receptor
molecular complex
Properties
COMPARTMENT: plasma membrane
SUBUNITS: interleukin-7 [IL-7] receptor-alpha
MOTIF: signal sequence {1-20}
N-glycosylation site {N49}
N-glycosylation site {N65}
fibronectin type III domain or F3 module {128-224}
MOTIF: N-glycosylation site {N151}
N-glycosylation site {N182}
threonine-rich region {184-189}
MOTIF: threonine residue (SEVERAL)
WSXWS motif {217-221}
N-glycosylation site {N232}
N-glycosylation site {N233}
transmembrane domain {240-264}
box1 motif
SITE: 272-280
FOR-BINDING-OF: Janus kinase (JAK)
Thr phosphorylation site {T282}
cytokine receptor common gamma chain
MOTIF: signal sequence {1-22}
N-glycosylation site {N24}
cysteine residue {C62}
MODIFICATION: cysteine residue {C72}
N-glycosylation site {N71}
cysteine residue {C72}
MODIFICATION: cysteine residue {C62}
N-glycosylation site {N75}
N-glycosylation site {N84}
cysteine residue {C102}
MODIFICATION: cysteine residue {C115}
cysteine residue {C115}
MODIFICATION: cysteine residue {C102}
fibronectin type III domain or F3 module {154-241}
MOTIF: N-glycosylation site {N159}
Thr phosphorylation site {T161}
cysteine residue {C182}
MODIFICATION: cysteine residue {C231}
cysteine residue {C231}
MODIFICATION: cysteine residue {C182}
WSXWS motif {237-241}
N-glycosylation site {N249}
transmembrane domain {263-283}
box1 motif
SITE: 286-294
FOR-BINDING-OF: Janus kinase (JAK)
Tyr phosphorylation site {Y325}
References
- Krantz SB.
Erythropoietin.
Blood. 1991 Feb 1;77(3):419-34. Review.
PMID: 1991159
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- Ihle JN et al
Signaling by the cytokine receptor superfamily: JAKs and STATs
TIBS 19:222 1994
PMID: 8048164
Components
CD127; CDw127; interleukin-7 [IL-7] receptor-alpha (IL7RA, IL7R)
CD132; cytokine receptor common gamma chain; gamma-C; interleukin-2 receptor gamma chain; IL-2R gamma chain; p64 (IL2RG)