Search
CD125; interleukin-5 receptor subunit alpha; IL-5R-alpha; CDw125; CD125 (IL5RA, IL5R)
Function:
- low affinity IL-5 receptor
- GM-CSF receptor, IL-3 receptor, & IL-5 receptor share a common beta subunit, KH97
Structure:
- the WSXWS motif appears to be necessary for proper proteinfolding, efficient intracellular transport & cell-surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 5 subfamily
Compartment: membrane
Alternative splicing: named isoforms=3
Expression: expressed on eosinophils & basophils
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
hematopoietin receptor superfamily
Properties
SIZE: entity length = 420 aa
MW = 48 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-20}
N-glycosylation site {N35}
N-glycosylation site {N131}
N-glycosylation site {N216}
N-glycosylation site {N244}
WSXWS motif {322-326}
transmembrane domain {343-362}
box1 motif
SITE: 371-379
FOR-BINDING-OF: Janus kinase (JAK)
Database Correlations
OMIM 147851
UniProt Q01344
Entrez Gene 3568
Kegg hsa:3568
References
- UniProt :accession Q01344
- SeattleSNPs
http://pga.gs.washington.edu/data/il5ra/
- Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ,
McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al.
The IL-6 signal transducer, gp130: an oncostatin M receptor
and affinity converter for the LIF receptor.
Science. 1992 Mar 13;255(5050):1434-7.
PMID: 1542794
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
Component-of
interleukin-5 receptor (IL5 receptor)