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interleukin-5 receptor (IL5 receptor)
Related
interleukin-5; IL-5; B-cell differentiation factor 1; eosinophil differentiation factor; T-cell replacing factor; TRF (IL5)
General
interleukin receptor
molecular complex
Properties
COMPARTMENT: plasma membrane
MOTIF: ligand-binding site
transmembrane domain
cysteine residue
box1 motif
FOR-BINDING-OF: Janus kinase (JAK)
box2 motif
FOR-BINDING-OF: Janus kinase (JAK)
Tyr phosphorylation site
SUBUNITS: IL-5 receptor alpha
MOTIF: signal sequence {1-20}
N-glycosylation site {N35}
N-glycosylation site {N131}
N-glycosylation site {N216}
N-glycosylation site {N244}
WSXWS motif {322-326}
transmembrane domain {343-362}
box1 motif
SITE: 371-379
FOR-BINDING-OF: Janus kinase (JAK)
cytokine receptor common subunit beta
MOTIF: signal sequence {1-16}
cysteine residue {C35}
MODIFICATION: cysteine residue {C45}
cysteine residue {C45}
MODIFICATION: cysteine residue {C35}
N-glycosylation site {N58}
cysteine residue {C75}
MODIFICATION: cysteine residue {C96}
cysteine residue {C86}
MODIFICATION: cysteine residue {C91}
cysteine residue {C91}
MODIFICATION: cysteine residue {C86}
cysteine residue {C96}
MODIFICATION: cysteine residue {C75}
fibronectin type III domain or F3 module {133-233}
MOTIF: N-glycosylation site {N191}
cysteine residue {C250}
MODIFICATION: cysteine residue {C260}
cysteine residue {C260}
MODIFICATION: cysteine residue {C250}
cysteine residue {C289}
MODIFICATION: cysteine residue {C306}
cysteine residue {C306}
MODIFICATION: cysteine residue {C289}
fibronectin type III domain or F3 module {338-432}
MOTIF: N-glycosylation site {N346}
WSXWS motif {425-429}
transmembrane domain {444-460}
box1 motif
SITE: 474-482
FOR-BINDING-OF: Janus Kinase 2 (JAK2)
Tyr phosphorylation site {Y766}
References
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
Components
CD125; interleukin-5 receptor subunit alpha; IL-5R-alpha; CDw125; CD125 (IL5RA, IL5R)
CDw131; cytokine receptor common subunit beta; KH97; GM-CSF/IL-3/IL-5 receptor common beta-chain; CDw131; CD131 (CSF2RB, IL3RB, IL5RB)