interleukin-4 receptor selections

interleukin-4 receptor (IL4 receptor)

Function: - combined IL-4 receptor & IL-13 receptor ? - activation of IL-4 receptor synergizes with PKC activation in inducing DNA synthesis in B cells - at least in part conveys signal through JAK3 - IL-4 response with role in promoting Th2 differentiation - IL4/IL13 responses with role in regulating IgE production &, chemokine & mucus production at sites of allergic inflammmation - in certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 - functional IL4 receptor is formed by initial binding of IL4 to IL4R. subsequent recruitment to the complex of the common gamma chain Structure: - heterodimer of IL-4 receptor alpha & common receptor gamma

General

interleukin receptor molecular complex

Properties

COMPARTMENT: plasma membrane CELL: B lymphocyte MOTIF: ligand-binding site transmembrane domain cysteine residue box1 motif FOR-BINDING-OF: Janus kinase (JAK) box2 motif FOR-BINDING-OF: Janus kinase (JAK) Tyr phosphorylation site SUBUNITS: interleukin-4 receptor alpha chain MOTIF: signal sequence {1-25} cysteine residue {C34} MODIFICATION: cysteine residue {C44} tyrosine residue {38} cysteine residue {C44} MODIFICATION: cysteine residue {C34} N-glycosylation site {N53} leucine residue {64} phenylalanine residue {66} cysteine residue {C74} MODIFICATION: cysteine residue {C86} cysteine residue {C86} MODIFICATION: cysteine residue {C74} aspartate residue {92} valine residue {94} aspartate residue {97} N-glycosylation site {N98} fibronectin type III domain or F3 module {123-219} MOTIF: N-glycosylation site {N128} N-glycosylation site {N134} tyrosine residue {152} N-glycosylation site {N176} tyrosine residue {208} N-glycosylation site {N209} WSXWS motif {212-216} transmembrane domain {233-256} box1 motif SITE: 262-270 FOR-BINDING-OF: Janus kinase (JAK) glutamate-rich region {370-380} MOTIF: glutamate residue (SEVERAL) IRS1 activation {437-557} MOTIF: Tyr phosphorylation site {Y497} IL4 expression {558-657} MOTIF: alanine-rich region {563-566} MOTIF: alanine residue (SEVERAL) Tyr phosphorylation site {Y575} Tyr phosphorylation site {Y603} Tyr phosphorylation site {Y631} immunoreceptor tyrosine-based inhibitory motif (ITIM) {711-716} serine-rich region {789-794} MOTIF: serine residue (SEVERAL) cytokine receptor common gamma chain MOTIF: signal sequence {1-22} N-glycosylation site {N24} cysteine residue {C62} MODIFICATION: cysteine residue {C72} N-glycosylation site {N71} cysteine residue {C72} MODIFICATION: cysteine residue {C62} N-glycosylation site {N75} N-glycosylation site {N84} cysteine residue {C102} MODIFICATION: cysteine residue {C115} cysteine residue {C115} MODIFICATION: cysteine residue {C102} fibronectin type III domain or F3 module {154-241} MOTIF: N-glycosylation site {N159} Thr phosphorylation site {T161} cysteine residue {C182} MODIFICATION: cysteine residue {C231} cysteine residue {C231} MODIFICATION: cysteine residue {C182} WSXWS motif {237-241} N-glycosylation site {N249} transmembrane domain {263-283} box1 motif SITE: 286-294 FOR-BINDING-OF: Janus kinase (JAK) Tyr phosphorylation site {Y325}

Database Correlations

OMIM 147781 MORBIDMAP 147781 Entrez Gene 3566

References

Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: 8048164
Klaus GG, Harnett MM. Cross-talk between B cell surface immunoglobulin and interleukin 4 receptors: the role of protein kinase C and Ca2(+)-mediated signals. Eur J Immunol. 1990 Oct;20(10):2301-7. PMID: 2173663
Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: 1334470
Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: 8048164
Entrez Gene :accession 3566

Components

CD124; interleukin-4 receptor alpha chain; IL-4R-alpha; sIL4Ralpha/prot; IL-4-binding protein; IL4-BP (IL4R, 582J21, IL4RA) CD132; cytokine receptor common gamma chain; gamma-C; interleukin-2 receptor gamma chain; IL-2R gamma chain; p64 (IL2RG)

Contents