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CD123; interleukin-3 receptor subunit alpha; IL-3R-alpha (IL3RA, IL3R)

Function: - subunit of interleukin-3 receptor (heterodimer) - low affinity IL-3 receptor - CSF2RB required for high-affinity receptor - associates with/caveolates lyn [6] Structure: - the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding - the box 1 motif is required for JAK interaction &/or activation - belongs to the type I cytokine receptor family, type 5 subfamily Compartment: membrane Note: - the gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X & Y chromosomes

Related

CD123 Ag in tissue CD123 blasts in blood CD123 blasts in bone marrow interleukin-3; erythrocyte burst-promoting factor; hematopoietic growth factor; mast-cell colony-stimulating factor; multipotential colony-stimulating factor; colony-stimulating factor-2 alpha; mast cell growth factor; P-cell stimulating factor (IL3, IL-3)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen hematopoietin receptor superfamily

Properties

SIZE: entity length = 378 aa MW = 43 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-18} N-glycosylation site {N46} N-glycosylation site {N64} N-glycosylation site {N80} N-glycosylation site {N109} N-glycosylation site {N212} N-glycosylation site {N218} WSXWS motif {282-286} transmembrane domain {306-325} box1 motif SITE: 334-342 FOR-BINDING-OF: Janus kinase (JAK)

Database Correlations

OMIM correlations UniProt P26951 Entrez Gene 3563 Kegg hsa:3563

References

  1. UniProt :accession P26951
  2. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/IL3RAID40959chXp22Yp13.html
  3. SeattleSNPs http://pga.gs.washington.edu/data/il3ra/
  4. Itoh N, Yonehara S, Schreurs J, Gorman DM, Maruyama K, Ishii A, Yahara I, Arai K, Miyajima A. Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science. 1990 Jan 19;247(4940):324-7. PMID: 2404337
  5. Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al. The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. Science. 1992 Mar 13;255(5050):1434-7. PMID: 1542794
  6. Bolen JB, Rowley RB, Spana C, Tsygankov AY. The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J. 1992 Dec;6(15):3403-9. Review. PMID: 1281458

Component-of

interleukin-3 receptor (IL3 receptor)