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interleukin-3 receptor (IL3 receptor)
Related
interleukin-3; erythrocyte burst-promoting factor; hematopoietic growth factor; mast-cell colony-stimulating factor; multipotential colony-stimulating factor; colony-stimulating factor-2 alpha; mast cell growth factor; P-cell stimulating factor (IL3, IL-3)
General
interleukin receptor
molecular complex
Properties
COMPARTMENT: plasma membrane
MOTIF: ligand-binding site
transmembrane domain
cysteine residue
box1 motif
FOR-BINDING-OF: Janus kinase (JAK)
box2 motif
FOR-BINDING-OF: Janus kinase (JAK)
Tyr phosphorylation site
SUBUNITS: IL-3 receptor alpha
MOTIF: signal sequence {1-18}
N-glycosylation site {N46}
N-glycosylation site {N64}
N-glycosylation site {N80}
N-glycosylation site {N109}
N-glycosylation site {N212}
N-glycosylation site {N218}
WSXWS motif {282-286}
transmembrane domain {306-325}
box1 motif
SITE: 334-342
FOR-BINDING-OF: Janus kinase (JAK)
cytokine receptor common subunit beta
MOTIF: signal sequence {1-16}
cysteine residue {C35}
MODIFICATION: cysteine residue {C45}
cysteine residue {C45}
MODIFICATION: cysteine residue {C35}
N-glycosylation site {N58}
cysteine residue {C75}
MODIFICATION: cysteine residue {C96}
cysteine residue {C86}
MODIFICATION: cysteine residue {C91}
cysteine residue {C91}
MODIFICATION: cysteine residue {C86}
cysteine residue {C96}
MODIFICATION: cysteine residue {C75}
fibronectin type III domain or F3 module {133-233}
MOTIF: N-glycosylation site {N191}
cysteine residue {C250}
MODIFICATION: cysteine residue {C260}
cysteine residue {C260}
MODIFICATION: cysteine residue {C250}
cysteine residue {C289}
MODIFICATION: cysteine residue {C306}
cysteine residue {C306}
MODIFICATION: cysteine residue {C289}
fibronectin type III domain or F3 module {338-432}
MOTIF: N-glycosylation site {N346}
WSXWS motif {425-429}
transmembrane domain {444-460}
box1 motif
SITE: 474-482
FOR-BINDING-OF: Janus Kinase 2 (JAK2)
Tyr phosphorylation site {Y766}
Database Correlations
OMIM 430000
Entrez Gene 3563
Kegg hsa/hsa04210
References
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- Entrez Gene :accession 3563
Components
CD123; interleukin-3 receptor subunit alpha; IL-3R-alpha (IL3RA, IL3R)
CDw131; cytokine receptor common subunit beta; KH97; GM-CSF/IL-3/IL-5 receptor common beta-chain; CDw131; CD131 (CSF2RB, IL3RB, IL5RB)