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CDw121b; interleukin-1 receptor type II; IL-1R-2; IL-1R-beta; CD121 antigen-like family member B; CDw121b; CD121b antigen; CD121 (IL1R2, IL1RB)
Function:
1) receptor for:
a) interleukin-1 alpha (IL-1A)
b) interleukin-1 beta (IL-1B)
c) interleukin-1 receptor antagonist protein (IL-1ra)
2) acts has decoy; binds but transduces no signal
Structure:
- belongs to the interleukin-1 receptor family
- contains 3 Ig-like C2-type domains (immunoglobulin-like)
Compartment: membrane
Expression:
- expression is enhanced by IL-4 & glucocorticoids
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
interleukin-1 receptor (IL1R)
phosphoprotein
Properties
SIZE: entity length = 398 aa
MW = 45 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-13}
immunoglobulin superfamily domain {18-124}
MOTIF: Thr phosphorylation site {T22}
cysteine residue {C50}
MODIFICATION: cysteine residue {C108}
N-glycosylation site {N66}
N-glycosylation site {N72}
cysteine residue {C108}
MODIFICATION: cysteine residue {C50}
Thr phosphorylation site {T109}
N-glycosylation site {N112}
immunoglobulin superfamily domain {134-223}
MOTIF: cysteine residue {C152}
MODIFICATION: cysteine residue {C207}
cysteine residue {C207}
MODIFICATION: cysteine residue {C152}
N-glycosylation site {N219}
immunoglobulin superfamily domain {237-349}
MOTIF: cysteine residue {C258}
MODIFICATION: cysteine residue {C326}
N-glycosylation site {N277}
cysteine residue {C326}
MODIFICATION: cysteine residue {C258}
transmembrane domain {344-369}
Database Correlations
OMIM 147811
UniProt P27930
Pfam PF00047
Entrez Gene 7850
Kegg hsa:7850
References
- UniProt :accession P27930
- SeattleSNPs
http://pga.gs.washington.edu/data/il1r2/
- Colotta F et al
Interleukin-1 type II receptor: a decoy target for IL-1 that
is regulated by IL-4.
Science. 1993 Jul 23;261(5120):472-5.
PMID: 8332913