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CDw121A, interleukin-1 receptor type I; IL-1R-1; IL-1RT1; IL-1R-alpha; p80; CD121 antigen-like family member A; CD121a (IL1R1, IL1RA, IL1RT1)

Function: 1) receptor for: a) interleukin-1 alpha (IL-1A) b) interleukin-1 beta (IL-1B) c) interleukin-1 receptor antagonist protein (IL-1RA) 2) binding of ligand leads to the activation of NF-kappa-B 3) signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, & IRAK1 or IRAK2 4) binds IL1RAP Structure: - belongs to the interleukin-1 receptor family - contains 3 Ig-like C2-type domains (immunoglobulin-like) - contains 1 TIR domain Compartment: membrane

Related

interleukin 1 receptor alpha in serum/plasma

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein interleukin-1 receptor (IL1R) immunoglobulin superfamily protein phosphoprotein

Properties

SIZE: entity length = 569 aa MW = 65 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-17} immunoglobulin superfamily domain {23-110} MOTIF: cysteine residue {C23} MODIFICATION: cysteine residue {C104} cysteine residue {C44} MODIFICATION: cysteine residue {C96} cysteine residue {C96} MODIFICATION: cysteine residue {C44} N-glycosylation site {N100} cysteine residue {C104} MODIFICATION: cysteine residue {C23} immunoglobulin superfamily domain {118-210} MOTIF: cysteine residue {C121} MODIFICATION: cysteine residue {C164} cysteine residue {C142} MODIFICATION: cysteine residue {C196} cysteine residue {C164} MODIFICATION: cysteine residue {C121} N-glycosylation site {N193} cysteine residue {C196} MODIFICATION: cysteine residue {C142} immunoglobulin superfamily domain {226-328} MOTIF: N-glycosylation site {N233} cysteine residue {C248} MODIFICATION: cysteine residue {C312} N-glycosylation site {N249} N-glycosylation site {N263} N-glycosylation site {N297} cysteine residue {C312} MODIFICATION: cysteine residue {C248} transmembrane domain {337-356} TIR domain {383-541} Thr phosphorylation site {T556} MISC-INFO: Kd 0.78 PM

References

  1. UniProt :accession P14778
  2. SeattleSNPs http://pga.gs.washington.edu/data/il1r1/
  3. O'Neill LA, Bird TA, Gearing AJ, Saklatvala J. Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). J Biol Chem. 1990 Feb 25;265(6):3146-52. PMID: 2154471
  4. Colotta F et al Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. Science. 1993 Jul 23;261(5120):472-5. PMID: 8332913

Databases & Figures

OMIM 147810 UniProt P14778 PFAM correlations Entrez Gene 3554 Kegg hsa:3554 TNFR/IL1R1/CD28/TCR-CD3 -> NF kappa B