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interleukin-1 receptor antagonist protein; IL-1ra; IL-1RN; IRAP; IL1 inhibitor; ICIL-1RA (IL1RN, IL1F3, IL1RA)

Function: - inhibits the activity of IL-1 by binding to its receptor - has no IL-1 like activity - has anti-inflammatory properties - secreted normally during inflammatory response - inhibits LPS-mediated stimulated production of: a) IL-1 beta b) TNF c) IL-6 d) GM-CSF - inhibits synthesis of IgE Compartment: - isoform 1: secreted - isoforms 2, 3 & 4: cytoplasm Alternative splicing: named isoforms=4 Expression: - the intracellular form of IL1RN is predominantly expressed in epithelial cells Pharmacology: - available under the name anakinra (Kineret from Amgen) - used for treatment of moderately to severely active rheumatoid arthritis Pathology: - SNP in IL-1RN associated with increased severity of osteoarthritis [8]

Related

interleukin-1 receptor (IL1R) interleukin-1 [IL-1] binding protein

Specific

anakinra (Kineret)

General

cytokine glycoprotein

Properties

SIZE: entity length = 177 aa MW = 20 kD COMPARTMENT: cytoplasm MOTIF: signal sequence {1-25} cysteine residue {C91} MODIFICATION: cysteine residue {C141} N-glycosylation site {N109} cysteine residue {C141} MODIFICATION: cysteine residue {C91}

Database Correlations

OMIM 147679 UniProt P18510 Pfam PF00340 Entrez Gene 3557 Kegg hsa:3557

References

  1. UniProt :accession P18510
  2. R&D systems' cytokine source book: IL-1ra http://www.rndsystems.com/molecule_detail.aspx?m=1637
  3. Wikipedia; interleukin-1 entry http://en.wikipedia.org/wiki/interleukin_1
  4. SeattleSNPs http://pga.gs.washington.edu/data/il1rn/
  5. SHMPD; The Singapore human mutation and polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1RN
  6. Kineret professional medical information http://www.kineretrx.com/professional/
  7. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  8. Wu X, Kondragunta V, Kornman KS et al IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort. Osteoarthritis Cartilage. 2013 Apr 18. PMID: 23602982