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interleukin-1 [IL-1] binding protein
A secreted form of IL-1 receptor 2
Function:
- acts has decoy
- binds IL-1 reducing IL-1 availability for interaction with IL-1 receptor 1
Expression: enhanced by IL-4 & glucocorticoids
Related
CDw121b; interleukin-1 receptor type II; IL-1R-2; IL-1R-beta; CD121 antigen-like family member B; CDw121b; CD121b antigen; CD121 (IL1R2, IL1RB)
interleukin-1 receptor antagonist protein; IL-1ra; IL-1RN; IRAP; IL1 inhibitor; ICIL-1RA (IL1RN, IL1F3, IL1RA)
General
secreted protein
Properties
SIZE: MW = 45 kD
COMPARTMENT: extracellular compartment
MOTIF: binding site
FOR-BINDING-OF: interleukin-1
MISC-INFO: Kd 0.78 PM
References
Colatta et al Science 261:472 1993