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interleukin-15 [IL-15] receptor-alpha; IL-15R-alpha; IL-15RA; sIL-15R-alpha; sIL-15RA (IL15RA)
Function:
1) receptor for interleukin-15
2) signal transduction involves STAT3, STAT5, STAT6, JAK2 & SYK
3) isoforms 6,7,8,9 do NOT bind IL-15
4) phosphorylated by activated SYK
5) soluble form sIL-15R-alpha binds IL-15, thus interferes with IL-15 binding to the membrane receptor
Structure:
- N & O-glycosylated
- contains 1 Sushi (CCP/SCR) domain
Compartment:
- mainly found associated with the nuclear membrane
- isoforms 6,7,8,9: endoplasmic reticulum membrane, Golgi, cytoplasmic vesicle membrane
- a soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor; cleavage involves ADAM17
Alternative splicing: named isoforms=9
Expression:
- expression of different isoforms may alter or interfere with signal transduction
- isoforms 1,3,4,5,6,7,8,9 are widely expressed
Related
interleukin-15 (IL15, IL-15)
General
glycoprotein
membrane protein
phosphoprotein
protein subunit
Properties
SIZE: MW = 28 kD
entity length = 267 aa
COMPARTMENT: cytoplasm
nuclear membrane
golgi
endoplasmic reticulum
MOTIF: signal sequence {1-30}
Sushi domain {31-95}
MOTIF: cysteine residue {C33}
MODIFICATION: cysteine residue {C75}
cysteine residue {C59}
MODIFICATION: cysteine residue {C93}
cysteine residue {C75}
MODIFICATION: cysteine residue {C33}
cysteine residue {C93}
MODIFICATION: cysteine residue {C59}
N-glycosylation site {N137}
transmembrane domain {206-226}
Tyr phosphorylation site {Y227}
FOR-PHOSPHORYLATION-BY: spleen tyrosine kinase
Database Correlations
OMIM 601070
UniProt Q13261
Entrez Gene 3601
Kegg hsa:3601
References
- OMIM :accession 601070
- Entrez Gene :accession 3601
- UniProt :accession Q13261
- SeattleSNPs
http://pga.gs.washington.edu/data/il15ra/
Component-of
interleukin-15 receptor