Search
interleukin-12 receptor beta-2 chain; IL-12 receptor beta-2; IL-12R-beta2 (IL12RB2)
Function:
- with I12RB1, forms functional high affinity IL12 receptor
- signaling component coupling to the JAK2/STAT4 pathway
- promotes the proliferation of T-cells as well as NK cells
- induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production
- Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain
- interaction, in vitro & in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation
- binds STAT4 through a membrane-distal C-terminal region
- on IL12 binding, phosphorylated on C-terminal Tyr by JAK2
- phosphorylation on Tyr-800 is required for STAT4 binding & activation, & for SOCS3 binding
Structure:
- the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 2 subfamily
- contains 5 fibronectin F3 modules
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- isoform 2 is expressed at similar levels in both naive & activated T-cells
- maximum levels in Th1 cells between day 3 & day 8 of activation
- in vitro, up-regulated by interferon alpha
Polymorphism:
- heterozygotic variants Gly-313 & Arg-720 are associated with atopy
General
glycoprotein
membrane protein
protein subunit
Properties
SIZE: entity length = 862 aa
MW = 97 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
N-glycosylation site {N48}
fibronectin type III domain or F3 module {124-218}
MOTIF: N-glycosylation site {N129}
N-glycosylation site {N166}
N-glycosylation site {N195}
serine-rich region {208-211}
MOTIF: serine residue (SEVERAL)
fibronectin type III domain or F3 module {224-316}
MOTIF: N-glycosylation site {N271}
WSXWS motif {305-309}
fibronectin type III domain or F3 module {317-415}
MOTIF: N-glycosylation site {N347}
N-glycosylation site {N376}
fibronectin type III domain or F3 module {420-517}
MOTIF: N-glycosylation site {N480}
fibronectin type III domain or F3 module {521-617}
transmembrane domain {623-643}
box1 motif
SITE: 662-670
FOR-BINDING-OF: Janus kinase (JAK)
proline-rich region
SITE: 750-753
MOTIF: proline residue (SEVERAL)
STAT4 binding {796-801}
MOTIF: Tyr phosphorylation site {Y800}
Database Correlations
OMIM 601642
UniProt Q99665
PFAM correlations
Entrez Gene 3595
Kegg hsa:3595
References
- UniProt :accession Q99665
- SeattleSNPs
http://pga.gs.washington.edu/data/il12rb2/
Component-of
interleukin-12 receptor