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interleukin-11 receptor alpha chain; IL-11R-alpha; IL-11RA (IL11RA)
Function:
- ligand-binding subunit for interleukin-11 receptor
- on ligand binding, forms a multimer complex with IL6ST/gp130
- receptor systems for IL6, LIF, OSM, CNTF, IL11 & CT1 utilize IL6ST/gp130 for initiating signal transduction
- the IL11/IL11RA/IL6ST complex may be involved in the control of proliferation &/or differentiation of skeletogenic progenitor or other mesenchymal cells
Structure:
- belongs to the type I cytokine receptor family, type 3 subfamily
- contains 2 fibronectin F3 modules
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
Compartment:
1) membrane
2) may be soluble form
Alternative splicing: named isoforms=2
Expression:
1) expressed cell lines, including
a) myelogenous leukemia
b) megakaryocytic leukemia cell line Mo7E
c) erythroleukemia cell line TF1
d) osteosarcoma cell lines, MG-63, Saos-2.
2) also expressed in normal & malignant prostate epithelial cell lines
Pathology:
- increased levels of IL11R are found in prostate carcinoma
Related
interleukin-11; IL-11; adipogenesis inhibitory factor; AGIF; oprelvekin (IL11)
General
glycoprotein
membrane protein
protein subunit
Properties
SIZE: entity length = 422 aa
MW = 45 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
immunoglobulin superfamily domain {27-110}
MOTIF: cysteine residue {C48}
MODIFICATION: cysteine residue {C94}
cysteine residue {C94}
MODIFICATION: cysteine residue {C48}
fibronectin type III domain or F3 module {112-214}
MOTIF: cysteine residue {C120}
MODIFICATION: cysteine residue {C130}
N-glycosylation site {N127}
cysteine residue {C130}
MODIFICATION: cysteine residue {C120}
cysteine residue {C170}
MODIFICATION: cysteine residue {C180}
cysteine residue {C180}
MODIFICATION: cysteine residue {C170}
N-glycosylation site {N194}
fibronectin type III domain or F3 module {218-311}
MOTIF: WSXWS motif {304-308}
transmembrane domain {371-391}
Database Correlations
OMIM 600939
UniProt Q14626
PFAM correlations
Entrez Gene 3590
Kegg hsa:3590
References
- UniProt :accession Q14626
- SeattleSNPs
http://pga.gs.washington.edu/data/il11ra/
Component-of
IL11/IL11RA/IL6ST complex