Search
CDw210a; interleukin-10 (IL-10) receptor alpha chain; IL-10R-A; IL-10R1 (IL10RA IL10R)
Function:
- along with IL10RB forms receptor for IL10
- binds IL10 with a high affinity
Structure: belongs to the type II cytokine receptor family
Compartment: membrane
Expression:
- expressed in spleen, thymus, & PBMC
- weak expression in pancreas, skeletal muscle, brain, heart, & kidney
- placenta, lung, & liver show intermediate levels
- monocytes, B-cells, large granular lymphocytes, & T-cells express high levels
Pathology:
- defects in IL10RA found in infantile-onset Crohn's disease
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
protein subunit
Properties
SIZE: entity length = 578 aa
MW = 63 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
N-glycosylation site {N50}
cysteine residue {C56}
MODIFICATION: cysteine residue {C75}
N-glycosylation site {N74}
cysteine residue {C75}
MODIFICATION: cysteine residue {C56}
N-glycosylation site {N110}
N-glycosylation site {N154}
N-glycosylation site {N177}
N-glycosylation site {N189}
cysteine residue {C202}
MODIFICATION: cysteine residue {C223}
cysteine residue {C223}
MODIFICATION: cysteine residue {C202}
transmembrane domain {236-256}
Database Correlations
OMIM 146933
UniProt Q13651
Entrez Gene 3587
Kegg hsa:3587
References
- UniProt :accession Q13651
- SeattleSNPs
http://pga.gs.washington.edu/data/il10ra/
- Glocker E-O et al.
Inflammatory bowel disease and mutations affecting the
interleukin-10 receptor.
N Engl J Med 2009 Nov 19; 361:2033
PMID: 19890111
- Kelsall B.
Interleukin-10 in inflammatory bowel disease.
N Engl J Med 2009 Nov 19; 361:2091.
PMID: 19890110
Component-of
interleukin-10 receptor (IL10 receptor)