ILK-PINCH complex

Function: - one of convergence points of integrin- & growth factor signaling pathways Structure: - consists of: ILK, PINCH

Properties

SUBUNITS: integrin-linked protein kinase COMPARTMENT: cytoplasm MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 2-30 ankyrin repeat NAME: ankyrin repeat SITE: 31-63 LIMS1 interaction {33-139} MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 64-96 ankyrin repeat NAME: ankyrin repeat SITE: 97-129 ankyrin repeat NAME: ankyrin repeat SITE: 130-174 PH-like; mediates interaction with TGFB1I1 {180-212} MOTIF: Ser phosphorylation site {S186} kinase domain SITE: 193-446 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 199-207 ATP-binding site NAME: ATP-binding site SITE: 220-220 STATE: active state LIM & senescent cell antigen-like-containing domain protein 1 COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl LIM domain {9-61} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {70-120} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {134-183} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {192-242} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site LIM domain {251-302} MOTIF: cysteine residue (6) histidine residue Zn+2-binding site

References

UniProt :accession P48059

Components

integrin-linked protein kinase; 59 kD serine/threonine protein kinase; ILK-1; ILK-2; p59ILK (ILK, ILK1, ILK2) LIM & senescent cell antigen-like-containing domain protein 1 (particularly interesting new Cys-His protein 1, PINCH-1, NY-REN-48 antigen, LIMS1, PINCH, PINCH1)