IL11/IL11RA/IL6ST complex

Function: - may be involved in the control of proliferation &/or differentiation of skeletogenic progenitor or other mesenchymal cells - the receptor systems for IL6, LIF, OSM, CNTF, IL11 & CT1 can utilize IL6ST for initiating signal transmission.

Properties

SUBUNITS: interleukin-11 COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-21} SECRETED-BY: bone marrow cell interleukin-11 receptor alpha chain COMPARTMENT: cellular membrane MOTIF: signal sequence {1-23} immunoglobulin superfamily domain {27-110} MOTIF: cysteine residue {C48} MODIFICATION: cysteine residue {C94} cysteine residue {C94} MODIFICATION: cysteine residue {C48} fibronectin type III domain or F3 module {112-214} MOTIF: cysteine residue {C120} MODIFICATION: cysteine residue {C130} N-glycosylation site {N127} cysteine residue {C130} MODIFICATION: cysteine residue {C120} cysteine residue {C170} MODIFICATION: cysteine residue {C180} cysteine residue {C180} MODIFICATION: cysteine residue {C170} N-glycosylation site {N194} fibronectin type III domain or F3 module {218-311} MOTIF: WSXWS motif {304-308} transmembrane domain {371-391} interleukin-6 receptor subunit beta COMPARTMENT: plasma membrane MOTIF: signal sequence {1-22} immunoglobulin superfamily domain {26-120} MOTIF: cysteine residue {C28} MODIFICATION: cysteine residue {C54} N-glycosylation site {N43} cysteine residue {C48} MODIFICATION: cysteine residue {C103} cysteine residue {C54} MODIFICATION: cysteine residue {C28} N-glycosylation site {N83} cysteine residue {C103} MODIFICATION: cysteine residue {C48} fibronectin type III domain or F3 module {125-216} MOTIF: N-glycosylation site {N131} cysteine residue {C134} MODIFICATION: cysteine residue {C144} cysteine residue {C144} MODIFICATION: cysteine residue {C134} N-glycosylation site {N157} cysteine residue {C172} MODIFICATION: cysteine residue {C182} cysteine residue {C182} MODIFICATION: cysteine residue {C172} fibronectin type III domain or F3 module {222-321} MOTIF: N-glycosylation site {N227} WSXWS motif {310-314} fibronectin type III domain or F3 module {326-418} MOTIF: N-glycosylation site {N379} N-glycosylation site {N383} fibronectin type III domain or F3 module {423-514} MOTIF: cysteine residue {C458} MODIFICATION: cysteine residue {C466} cysteine residue {C466} MODIFICATION: cysteine residue {C458} fibronectin type III domain or F3 module {518-610} MOTIF: N-glycosylation site {N553} N-glycosylation site {N564} transmembrane domain {620-641} box1 motif SITE: 651-659 FOR-BINDING-OF: Janus kinase (JAK) Ser phosphorylation site {S667} serine-rich region {725-755} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S782} Ser phosphorylation site {S820} Ser phosphorylation site {S829}

References

UniProt :accession Q14626

Components

CD130; gp130; interleukin-6 receptor subunit beta; IL-6R-beta; interleukin-6 signal transducer; membrane glycoprotein 130; CDw130; oncostatin-M receptor alpha subunit (IL6ST) interleukin-11 receptor alpha chain; IL-11R-alpha; IL-11RA (IL11RA) interleukin-11; IL-11; adipogenesis inhibitory factor; AGIF; oprelvekin (IL11)