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CD179a; immunoglobulin iota chain; CD179 antigen-like family member A; protein VpreB1; V(pre)B protein; VpreB protein (VPREB1, VPREB)
Function:
- associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells
- this complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation
- associates non-covalently with IGLL1
Structure:
- belongs to the immunoglobulin superfamily
- contains 1 Ig-like V-type domain
Expression: only expressed by pre-B-cells
Laboratory:
- CD179a blasts in specimen
- cytoplasmic CD179a blasts in specimen
- CD179a blasts in blood
- cytoplasmic CD179a blasts in blood
- CD179a blasts in bone marrow
- cytoplasmic CD179a blasts in bone marrow
Related
CD179a blasts in blood
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
protein subunit
Properties
SIZE: entity length = 145 aa
MW = 17 kD
MOTIF: signal sequence {1-19}
glycosylation site
membrane region
immunoglobulin superfamily domain {20-132}
MOTIF: Framework-1 {20-41}
cysteine residue {C41}
MODIFICATION: cysteine residue {C115}
Complementarity-determining-1 {42-56}
Framework-2 {57-70}
Complementarity-determining-2 {71-81}
Framework-3 {82-115}
cysteine residue {C115}
MODIFICATION: cysteine residue {C41}
Database Correlations
OMIM 605141
UniProt P12018
Pfam PF07686
Entrez Gene 7441
Kegg hsa:7441
References
- UniProt :accession P12018
- Wikipedia; Note: VPREB1
http://en.wikipedia.org/wiki/VPREB1