Search
CD89; immunoglobulin alpha Fc receptor; IgA Fc receptor (FCAR)
Function:
- mediates
a) cytokine production
b) phagocytosis
c) antibody-dependent cell-mediated cytotoxicity
d) release of inflammatory mediators
- binds Fc region of IgA
- associates with & induces tyrosine phosphorylation of Fc epsilon RI gamma 2 receptor
Structure:
- contains 2 Ig-like C2-type domains (immunoglobulin-like)
Compartment:
- membrane (isoform A)
- secreted (isoform B)
Alternative splicing: named isoforms=6; A.1,A.2,A.2,B,B-delta
Expression:
- granulocyte lineage cells
- monocytes (isoforms A.1, A.2 & A.3)
- activated eosinophils
- alveolar macrophages (isoforms A.1 & A.2)
- splenic macrophages
- cells express only one isoform at their surfaces
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
immunoglobulin superfamily protein
Properties
SIZE: MW = 32 kD
entity length = 287 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
immunoglobulin superfamily domain {42-107}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C100}
Tyr phosphorylation site {Y56}
N-glycosylation site {N65}
N-glycosylation site {N79}
cysteine residue {C100}
MODIFICATION: cysteine residue {C49}
immunoglobulin superfamily domain {139-200}
MOTIF: N-glycosylation site {N141}
cysteine residue {C146}
MODIFICATION: cysteine residue {C193}
N-glycosylation site {N177}
N-glycosylation site {N186}
cysteine residue {C193}
MODIFICATION: cysteine residue {C146}
N-glycosylation site {N198}
transmembrane domain {228-246}
Database Correlations
OMIM 147045
UniProt P24071
Pfam PF00047
Entrez Gene 2204
Kegg hsa:2204
References
- UniProt :accession P24071
- http://www.pathologyoutlines.com/cdmarkers.html
4 May 2004
- Protein Reviews on the Web
http://mpr.nci.nih.gov/prow/guide/