IgGFc-binding protein (FcgammaBP, Fcgamma-binding protein antigen, FCGBP)

Function: - may be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa - interacts with the Fc portion of IgG Structure: - contains 12 TIL domains (trypsin inhibitory-like domains) - contains 13 VWFD domains - N-terminal IgGFc-binding region is primate-specific Compartment: secreted (probable) Expression: - mainly expressed in placenta & colon epithelium - expressed in thyroid - present in serum, with higher levels in patients with various autoimmune disases (at protein level) Pathology: - down-regulated in thyroid carcinomas - increased serum levels in patients with various autoimmune disases

General

glycoprotein secreted protein

Properties

SIZE: MW = 572 kD entity length = 5405 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-23} binding site SITE: 24-450 FOR-BINDING-OF: IGGFC MOTIF: N-glycosylation site {N75} N-glycosylation site {N91} VWFD domain {471-690} MOTIF: cysteine residue {C494} MODIFICATION: cysteine residue {C502} cysteine residue {C502} MODIFICATION: cysteine residue {C494} cysteine-rich region {741-847} MOTIF: TIL 1 {745-799} VWFD domain {863-1081} MOTIF: cysteine residue {C886} MODIFICATION: cysteine residue {C894} cysteine residue {C894} MODIFICATION: cysteine residue {C886} cysteine-rich region {1132-1235} MOTIF: TIL 2 {1136-1189} VWFD domain {1251-1477} MOTIF: cysteine residue {C1274} MODIFICATION: cysteine residue {C1282} cysteine residue {C1282} MODIFICATION: cysteine residue {C1274} cysteine-rich region {1528-1656} MOTIF: TIL 3 {1532-1585} VWFD domain {1672-1895} MOTIF: cysteine residue {C1695} MODIFICATION: cysteine residue {C1704} cysteine residue {C1704} MODIFICATION: cysteine residue {C1695} N-glycosylation site {N1743} TIL 4 {1950-2007} VWFD domain {2071-2282} MOTIF: cysteine residue {C2094} MODIFICATION: cysteine residue {C2102} cysteine residue {C2102} MODIFICATION: cysteine residue {C2094} N-glycosylation site {N2138} cysteine-rich region {2333-2436} MOTIF: TIL 5 {2337-2390} VWFD domain {2452-2678} MOTIF: cysteine residue {C2475} MODIFICATION: cysteine residue {C2483} cysteine residue {C2483} MODIFICATION: cysteine residue {C2475} N-glycosylation site {N2518} cysteine-rich region {2729-2857} MOTIF: TIL 6 {2733-2786} VWFD domain {2873-3096} MOTIF: cysteine residue {C2896} MODIFICATION: cysteine residue {C2905} cysteine residue {C2905} MODIFICATION: cysteine residue {C2896} TIL 7 {3151-3208} VWFD domain {3272-3483} MOTIF: cysteine residue {C3295} MODIFICATION: cysteine residue {C3303} cysteine residue {C3303} MODIFICATION: cysteine residue {C3295} cysteine-rich region {3534-3637} MOTIF: TIL 8 {3538-3591} VWFD domain {3653-3879} MOTIF: cysteine residue {C3676} MODIFICATION: cysteine residue {C3684} cysteine residue {C3684} MODIFICATION: cysteine residue {C3676} N-glycosylation site {N3719} cysteine-rich region {3930-4058} MOTIF: TIL 9 {3934-3987} VWFD domain {4074-4297} MOTIF: cysteine residue {C4097} MODIFICATION: cysteine residue {C4106} cysteine residue {C4106} MODIFICATION: cysteine residue {C4097} TIL 10 {4352-4409} VWFD domain {4473-4684} MOTIF: cysteine residue {C4496} MODIFICATION: cysteine residue {C4504} cysteine residue {C4504} MODIFICATION: cysteine residue {C4496} TIL 11 {4739-4792} VWFD domain {4855-5066} MOTIF: cysteine residue {C4878} MODIFICATION: cysteine residue {C4886} cysteine residue {C4886} MODIFICATION: cysteine residue {C4878} cysteine-rich region {5117-5219} MOTIF: TIL 12 {5121-5174} VWFD domain {5234-5405}

Database Correlations

UniProt Q9Y6R7 PFAM correlations

References

UniProt :accession Q9Y6R7