IGF-binding protein complex acid labile subunit; ALS (IGFALS, ALS)

Function: - role in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion - forms a ternary complex of about 140 to 150 kD with IGF-1 or IGF-2 & IGFBP-3 (IGF1-IGFBP3-ALS) Structure: - contains 19 LRR repeats (leucine-rich repeats) - contains 1 LRRCT domain - contains 1 LRRNT domain Compartment: secreted, extracellular space Expression: plasma

General

glycoprotein insulin-like growth factor [IGF]-binding protein leucine-rich repeat-containing protein (LRRC)

Properties

SIZE: entity length = 605 aa MW = 66 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-27} LRRNT {32-74} MOTIF: N-glycosylation site {N64} leucine-rich repeat SITE: 75-96 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N85} N-glycosylation site {N96} leucine-rich repeat SITE: 99-120 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 123-144 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 147-168 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 171-192 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 195-216 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 219-240 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 243-264 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 267-288 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 291-312 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 315-336 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 339-360 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 363-384 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N368} leucine-rich repeat SITE: 387-408 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 411-432 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 435-456 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 459-480 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 483-504 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 507-528 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N515} LRRCT {536-605} MOTIF: N-glycosylation site {N580} SECRETED-BY: hepatocyte smooth muscle

Database Correlations

OMIM 601489 MORBIDMAP 601489 UniProt P35858 PFAM correlations Entrez Gene 3483 Kegg hsa:3483

References

UniProt :accession P35858