Search
insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6 (IGFBP6 IBP6)
Function:
- IGF-binding proteins prolong the half-life of the IGFs
- they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
- they alter the interaction of IGFs with their cell surface receptors
Structure:
- O-glycosylated
- O-linked glycans consist of hexose (probably gal), N-acetylhexosamine (probably galNAc) & sialic acid residues
- O-glycosylated with core 1 glycan or possibly core 8 glycan
- O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid
- contains 1 IGFBP N-terminal domain
- contains 1 thyroglobulin type-1 domain
Compartment: secreted
General
glycoprotein
insulin-like growth factor [IGF]-binding protein
Properties
SIZE: entity length = 240 aa
MW = 25 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
IGFBP N-terminal {28-107}
MOTIF: cysteine residue {C29}
MODIFICATION: cysteine residue {C32}
cysteine residue {C32}
MODIFICATION: cysteine residue {C29}
cysteine residue {C40}
MODIFICATION: cysteine residue {C44}
cysteine residue {C44}
MODIFICATION: cysteine residue {C40}
cysteine residue {C57}
MODIFICATION: cysteine residue {C63}
cysteine residue {C63}
MODIFICATION: cysteine residue {C57}
cysteine residue {C71}
MODIFICATION: cysteine residue {C84}
cysteine residue {C78}
MODIFICATION: cysteine residue {C104}
cysteine residue {C84}
MODIFICATION: cysteine residue {C71}
cysteine residue {C104}
MODIFICATION: cysteine residue {C78}
Thr glycosylation site {T126}
Ser glycosylation site {S144}
Thr glycosylation site {T145}
Thr glycosylation site {T146}
Ser glycosylation site {S152}
Thyroglobulin type-1 {160-234}
MOTIF: cysteine residue {C163}
MODIFICATION: cysteine residue {C190}
cysteine residue {C190}
MODIFICATION: cysteine residue {C163}
cysteine residue {C201}
MODIFICATION: cysteine residue {C212}
cysteine residue {C212}
MODIFICATION: cysteine residue {C201}
cysteine residue {C214}
MODIFICATION: cysteine residue {C234}
cysteine residue {C234}
MODIFICATION: cysteine residue {C214}
SECRETED-BY: hepatocyte
smooth muscle
Database Correlations
OMIM 146735
UniProt P24592
PFAM correlations
Entrez Gene 3489
Kegg hsa:3489
References
- UniProt :accession P24592
- NIEHS-SNPs
http://egp.gs.washington.edu/data/igfbp6/
- Entrez Gene :accession 3489