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insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; IGFBP-4 (IGFBP4, IBP4)
Function:
- IGF-binding proteins prolong the half-life of the IGFs
- they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
- they alter the interaction of IGFs with their cell surface receptors
- binds IGF2 more than IGF1
Structure:
- contains 1 IGFBP N-terminal domain
- contains 1 thyroglobulin type-1 domain
Compartment: secreted
Expression:
- induced by forskolin & N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate
- not induced by 1,9 dideoxyforskolin
General
glycoprotein
insulin-like growth factor [IGF]-binding protein
Properties
SIZE: entity length = 258 aa
MW = 28 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
IGFBP N-terminal {23-103}
MOTIF: cysteine residue {C27}
MODIFICATION: cysteine residue {C53}
cysteine residue {C30}
MODIFICATION: cysteine residue {C55}
cysteine residue {C38}
MODIFICATION: cysteine residue {C59}
cysteine residue {C44}
MODIFICATION: cysteine residue {C56}
cysteine residue {C53}
MODIFICATION: cysteine residue {C27}
cysteine residue {C55}
MODIFICATION: cysteine residue {C30}
cysteine residue {C56}
MODIFICATION: cysteine residue {C44}
cysteine residue {C59}
MODIFICATION: cysteine residue {C38}
cysteine residue {C67}
MODIFICATION: cysteine residue {C80}
cysteine residue {C74}
MODIFICATION: cysteine residue {C100}
cysteine residue {C80}
MODIFICATION: cysteine residue {C67}
cysteine residue {C100}
MODIFICATION: cysteine residue {C74}
N-glycosylation site {N125}
cysteine residue {C131}
MODIFICATION: cysteine residue {C138}
cysteine residue {C138}
MODIFICATION: cysteine residue {C131}
Thyroglobulin type-1 {171-249}
MOTIF: cysteine residue {C174}
MODIFICATION: cysteine residue {C204}
cysteine residue {C204}
MODIFICATION: cysteine residue {C174}
cysteine residue {C215}
MODIFICATION: cysteine residue {C226}
cysteine residue {C226}
MODIFICATION: cysteine residue {C215}
cysteine residue {C228}
MODIFICATION: cysteine residue {C249}
cysteine residue {C249}
MODIFICATION: cysteine residue {C228}
SECRETED-BY: hepatocyte
smooth muscle
Database Correlations
OMIM 146733
UniProt P22692
PFAM correlations
Entrez Gene 3487
Kegg hsa:3487
References
- UniProt :accession P22692
- NIEHS-SNPs
http://egp.gs.washington.edu/data/igfbp4/
- Entrez Gene :accession 3487