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insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2 (IGFBP2, BP2, IBP2)
Function:
- IGF-binding proteins prolong the half-life of the IGFs
- they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
- they alter the interaction of IGFs with their cell surface receptors
- inhibits IGF-mediated growth & developmental rates
- binds IGF2 more than IGF1
- predominate form of IGF binding protein found in human & rat CSF & CNS is IGF-BP2 with 3 N-terminal amino acids truncated
Structure:
- O-glycosylated
- C-terminus is required for IGF-binding & growth inhibition
- contains 1 IGFBP N-terminal domain
- contains 1 thyroglobulin type-1 domain
Compartment: secreted
General
insulin-like growth factor [IGF]-binding protein
Properties
SIZE: entity length = 325 aa
MW = 35 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-35}
IGFBP N-terminal {38-134}
Thyroglobulin type-1 {224-306}
MOTIF: cysteine residue {C227}
MODIFICATION: cysteine residue {C261}
cysteine residue {C261}
MODIFICATION: cysteine residue {C227}
cysteine residue {C272}
MODIFICATION: cysteine residue {C283}
cysteine residue {C283}
MODIFICATION: cysteine residue {C272}
cysteine residue {C285}
MODIFICATION: cysteine residue {C306}
Cell attachment site {301-303}
cysteine residue {C306}
MODIFICATION: cysteine residue {C285}
SECRETED-BY: hepatocyte
smooth muscle
Database Correlations
OMIM 146731
UniProt P18065
PFAM correlations
Entrez Gene 3485
Kegg hsa:3485
References
- UniProt :accession P18065
- NIEHS-SNPs
http://egp.gs.washington.edu/data/igfbp2/
- LeRoith et al, in: Insulin-like growth factors in the
brain. Neurotrophic Factors, Academic Press 1993,
pg 391
- Entrez Gene :accession 3485