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insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; placental protein 12; PP12 (IGFBP1, IBP1)
Function:
- IGF-binding proteins prolong the half-life of the IGFs
- they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
- they alter the interaction of IGFs with their cell surface receptors
- promotes cell migration
- phosphorylated, probably by casein kinase II
- phosphorylation alters the affinity of the protein for IGFs
- in amniotic fluid, the unmodified protein is the most abundant form
- mono-phosphorylated di-phosphorylated, tri-phosphorylated & tetra-phosphorylated forms are present in decreasing amounts
- phosphorylation state may influence the propensity to proteolysis
- binds equally well IGF1 & IGF2
Structure:
- contains 1 IGFBP N-terminal domain
- contains 1 thyroglobulin type-1 domain
Compartment: secreted
General
insulin-like growth factor [IGF]-binding protein
phosphoprotein
placental protein
Properties
SIZE: entity length = 259 aa
MW = 28 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
IGFBP N-terminal {26-107}
MOTIF: cysteine residue {C71}
MODIFICATION: cysteine residue {C84}
cysteine residue {C78}
MODIFICATION: cysteine residue {C104}
cysteine residue {C84}
MODIFICATION: cysteine residue {C71}
cysteine residue {C104}
MODIFICATION: cysteine residue {C78}
Ser phosphorylation site {S120}
Ser phosphorylation site {S123}
Ser phosphorylation site {S126}
Ser phosphorylation site {S144}
Thyroglobulin type-1 {173-251}
MOTIF: cysteine residue {C176}
MODIFICATION: cysteine residue {C206}
Ser phosphorylation site {S194}
cysteine residue {C206}
MODIFICATION: cysteine residue {C176}
cysteine residue {C217}
MODIFICATION: cysteine residue {C228}
cysteine residue {C228}
MODIFICATION: cysteine residue {C217}
cysteine residue {C230}
MODIFICATION: cysteine residue {C251}
Cell attachment site {246-248}
cysteine residue {C251}
MODIFICATION: cysteine residue {C230}
SECRETED-BY: hepatocyte
smooth muscle
Database Correlations
OMIM 146730
UniProt P08833
PFAM correlations
Entrez Gene 3484
Kegg hsa:3484
References
- UniProt :accession P08833
- NIEHS-SNPs
http://egp.gs.washington.edu/data/igfbp1/
- LeRoith et al, in: Insulin-like growth factors in the
brain. Neurotrophic Factors, Academic Press 1993,
pg 391
- Entrez Gene :accession 3484