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insulin-like growth factor [IGF]-binding protein

Function: - IGF-binding proteins prolong the half-life of the IGFs - thery either inhibit or stimulate the growth promoting effects of the IGFs on cell culture - they alter the interaction of IGFs with their cell surface receptors

Specific

IGF-binding protein complex acid labile subunit; ALS (IGFALS, ALS) insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; placental protein 12; PP12 (IGFBP1, IBP1) insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2 (IGFBP2, BP2, IBP2) insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3 (IGFBP3, IBP3) insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; IGFBP-4 (IGFBP4, IBP4) insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5 (IGFBP5 IBP5) insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6 (IGFBP6 IBP6) insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; prostacyclin-stimulating factor; tumor-derived adhesion factor; TAF (IGFBP7, MAC25, PSF) insulin-like growth factor-binding protein-like 1 (insulin-like growth factor-binding-related protein 4, IGFBP-related protein 10, IGFBP-rP4, IGFBPL1, IGFBPRP4)

General

secreted protein

Properties

COMPARTMENT: extracellular compartment MOTIF: cysteine-rich region binding site FOR-BINDING-OF: somatomedin SECRETED-BY: hepatocyte smooth muscle

References

  1. LeRoith et al, in: Insulin-like growth factors in the brain. Neurotrophic Factors, Academic Press 1993, pg 391