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IGF-1/IGF binding protein 3/acid-labile subunit glycoprotein
Function:
- 85% of IGF-1 is bound in molecular complex with IGF-binding protein 3 & acid labile subunit glycoprotein
- this prolongs 1/2life of IGF-1 from 10 minutes to 12 hours & renders IGF-1 inactive
Structure:
- ternary complex of IGF-1, IGFBP-3 & ALS
General
membrane protein
molecular complex
Properties
SIZE: MW = 150 kD
COMPARTMENT: cellular membrane
MOTIF: membrane region
SUBUNITS: insulin-like growth factor-1
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
B {49-77}
MOTIF: cysteine residue {C54}
MODIFICATION: cysteine residue {C96}
cysteine residue {C66}
MODIFICATION: cysteine residue {C109}
C {78-89}
A {90-110}
MOTIF: cysteine residue {C95}
MODIFICATION: cysteine residue {C100}
cysteine residue {C96}
MODIFICATION: cysteine residue {C54}
cysteine residue {C100}
MODIFICATION: cysteine residue {C95}
cysteine residue {C109}
MODIFICATION: cysteine residue {C66}
D {111-118}
SECRETED-BY: macrophage
GENE: IGF-1 gene
insulin-like growth factor-binding protein 3
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
binding site
SITE: 28-134
FOR-BINDING-OF: insulin-like growth factor (IGF)
MOTIF: IGFBP N-terminal {36-117}
N-glycosylation site {N116}
N-glycosylation site {N136}
threonine-rich region {138-161}
MOTIF: threonine residue (SEVERAL)
threonine-rich region {192-208}
MOTIF: threonine residue (SEVERAL)
Thr phosphorylation site {T195}
N-glycosylation site {N199}
Ser phosphorylation site {S201}
Thyroglobulin type-1 {210-285}
MOTIF: cysteine residue {C213}
MODIFICATION: cysteine residue {C240}
cysteine residue {C240}
MODIFICATION: cysteine residue {C213}
cysteine residue {C251}
MODIFICATION: cysteine residue {C262}
cysteine residue {C262}
MODIFICATION: cysteine residue {C251}
cysteine residue {C264}
MODIFICATION: cysteine residue {C285}
cysteine residue {C285}
MODIFICATION: cysteine residue {C264}
SECRETED-BY: hepatocyte
smooth muscle
IGF-binding protein complex acid labile subunit
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
LRRNT {32-74}
MOTIF: N-glycosylation site {N64}
leucine-rich repeat
SITE: 75-96
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N85}
N-glycosylation site {N96}
leucine-rich repeat
SITE: 99-120
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 123-144
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 147-168
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 171-192
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 195-216
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 219-240
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 243-264
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 267-288
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 291-312
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 315-336
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 339-360
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 363-384
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N368}
leucine-rich repeat
SITE: 387-408
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 411-432
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 435-456
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 459-480
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 483-504
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 507-528
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N515}
LRRCT {536-605}
MOTIF: N-glycosylation site {N580}
SECRETED-BY: hepatocyte
smooth muscle
References
Internal Medicine News, April 15, 2005
Components
IGF-binding protein complex acid labile subunit; ALS (IGFALS, ALS)
insulin-like growth factor-1; mechano growth factor; MGF; somatomedin-C (IGF1, IBP1)
insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3 (IGFBP3, IBP3)