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immunoglobulin-E (IgE)
Binds to mast cells.
Mediates type I hypersensitivity reactions (allergy).
50% of IgE is intravascular.
Also present in respiratory & gastrointestinal mucosa.
Laboratory:
- IgE in blood
- IgE in CSF
- IgE in nasal fluid
- IgE in serum
- IgE monoclonal in serum
- IgE in urine
Interactions
molecular events
Related
hyperimmunoglobulin E (Job's syndrome)
IgE Ag in tissue
IgE in serum
immunoglobulin E [IgE] receptor or Fc epsilon [IgE] receptor-1
mast cell
rhuMAB-E25
type 4 hypersensitivity; T-cell-mediated (delayed) hypersensitivity
General
immunoglobulin
Properties
SIZE: MW = 190 kD
COMPARTMENT: plasma
SECRETED-BY: plasma cell
SUBUNITS: immunoglobulin epsilon chain (Ig-epsilon) (2)
MOTIF: Ig heavy chain variable region
NAME: Ig heavy chain variable region
heavy chain constant region-1
MOTIF: cysteine residue {CH1.SITE1}
MODIFICATION: cysteine residue {CH1.SITE2}
cysteine residue {CH1.SITE2}
MODIFICATION: cysteine residue {CH1.SITE1}
cysteine residue {C-TO-CH1}
MODIFICATION: cysteine residue {C-TO-CL}
hinge region
MOTIF: cysteine residue {HINGE1}
MODIFICATION: cysteine residue {HINGE1}
cysteine residue {HINGE2}
MODIFICATION: cysteine residue {HINGE2}
heavy chain constant region-2
MOTIF: cysteine residue {CH2.SITE1}
MODIFICATION: cysteine residue {CH2.SITE2}
cysteine residue {CH2.SITE2}
MODIFICATION: cysteine residue {CH2.SITE1}
heavy chain constant region-3
MOTIF: cysteine residue {CH3.SITE1}
MODIFICATION: cysteine residue {CH3.SITE2}
cysteine residue {CH3.SITE2}
MODIFICATION: cysteine residue {CH3.SITE1}
heavy chain constant region-4
MOTIF: cysteine residue {CH4.SITE1}
MODIFICATION: cysteine residue {CH4.SITE2}
cysteine residue {CH4.SITE2}
MODIFICATION: cysteine residue {CH4.SITE1}
immunoglobulin light chain (2)
MOTIF: Ig light chain variable region
NAME: Ig light chain variable region
light chain constant region
MOTIF: cysteine residue {CLSITE1}
MODIFICATION: cysteine residue {CL.SITE2}
cysteine residue {CL.SITE2}
MODIFICATION: cysteine residue {CL.SITE1}
cysteine residue {C-TO-CL}
MODIFICATION: cysteine residue {C-TO-CH1}
MISC-INFO: CONCENTRATION 5-60 UG/DL
Database Correlations
OMIM 147050
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- Clinical Diagnosis & Management by Laboratory Methods,
19th edition, J.B. Henry (ed), W.B. Saunders Co.,
Philadelphia, PA. 1996, pg 1051-1062
Components
immunoglobulin epsilon chain (Ig-epsilon)
immunoglobulin light chain