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interferon [IFN] gamma receptor
Putative receptor associated molecule, so far unidentified [From ref 1]. It is assumed that IFN-gamma receptor alpha is identical to the IFN-gamma receptor in ref 1 & that IFN-gamma receptor beta is the accessory factor. Both JAK1 & JAK2 must be present for functional activation via the IFN-gamma receptor.
General
interferon receptor
molecular complex
Properties
COMPARTMENT: plasma membrane
MOTIF: ligand-binding site
transmembrane domain
cysteine residue
box1 motif
FOR-BINDING-OF: Janus kinase (JAK)
box2 motif
FOR-BINDING-OF: Janus kinase (JAK)
Tyr phosphorylation site
SUBUNITS: interferon [IFN] gamma receptor alpha
MOTIF: signal sequence {1-17}
N-glycosylation site {N34}
cysteine residue {C77}
MODIFICATION: cysteine residue {C85}
N-glycosylation site {N79}
cysteine residue {C85}
MODIFICATION: cysteine residue {C77}
N-glycosylation site {N86}
cysteine residue {C122}
MODIFICATION: cysteine residue {C167}
cysteine residue {C167}
MODIFICATION: cysteine residue {C122}
N-glycosylation site {N179}
cysteine residue {C195}
MODIFICATION: cysteine residue {C200}
cysteine residue {C200}
MODIFICATION: cysteine residue {C195}
cysteine residue {C214}
MODIFICATION: cysteine residue {C235}
cysteine residue {C235}
MODIFICATION: cysteine residue {C214}
N-glycosylation site {N240}
transmembrane domain {246-266}
Ser phosphorylation site {S369}
IFN-gamma receptor beta chain
MOTIF: signal sequence {1-27}
fibronectin type III domain or F3 module {31-129}
MOTIF: N-glycosylation site {N56}
N-glycosylation site {N85}
N-glycosylation site {N110}
N-glycosylation site {N137}
fibronectin type III domain or F3 module {139-229}
MOTIF: Ser phosphorylation site {S198}
N-glycosylation site {N219}
N-glycosylation site {N231}
transmembrane domain {248-268}
References
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- Ihle JN et al
Signaling by the cytokine receptor superfamily: JAKs and STATs
TIBS 19:222 1994
PMID: 8048164
Components
CDw119; interferon-gamma receptor alpha chain; IFN-gamma-R1; CD119 (IFNGR1)
interferon (IFN)-gamma receptor beta chain; interferon-gamma receptor accessory factor 1; AF-1; interferon-gamma transducer 1 (IFNGR2, IFNGT1)