interferon-alpha/beta receptor alpha chain; IFN-alpha-REC (IFNAR1, IFNAR)

Function: - receptor for IFN-alpha & IFN-beta - binding to type 1 IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins & IFNR alpha- & IFNR beta-subunits themselves - phosphorylated on Tyr by TYK2 tyrosine kinase Structure: - belongs to the type 2 cytokine receptor family - contains 3 fibronectin F3 modules Compartment: isoform 1: membrane Alternative splicing: named isoforms=3 Expression: - IFN receptors are present in all tissues & even on the surface of most IFN-resistant cells - isoform 1, isoform 2 & isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266S - isoform 2 & isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R - isoform 1 is not expressed in U266R

Related

interferon beta; IFN-beta; fibroblast interferon (IFNB1, IFB, IFNB) interferon [IFN]-alpha

General

glycoprotein interferon receptor phosphoprotein

Properties

SIZE: entity length = 557 aa MW = 64 kD COMPARTMENT: plasma membrane MOTIF: signal sequence {1-27} N-glycosylation site {N50} N-glycosylation site {N58} cysteine residue {C79} MODIFICATION: cysteine residue {C87} N-glycosylation site {N81} cysteine residue {C87} MODIFICATION: cysteine residue {C79} N-glycosylation site {N88} N-glycosylation site {N110} fibronectin type III domain or F3 module {134-224} MOTIF: N-glycosylation site {N172} cysteine residue {C199} MODIFICATION: cysteine residue {C220} cysteine residue {C220} MODIFICATION: cysteine residue {C199} fibronectin type III domain or F3 module {230-326} MOTIF: N-glycosylation site {N254} N-glycosylation site {N313} N-glycosylation site {N314} fibronectin type III domain or F3 module {334-425} MOTIF: N-glycosylation site {N376} N-glycosylation site {N416} N-glycosylation site {N433} transmembrane domain {437-457} Tyr phosphorylation site {Y466} Tyr phosphorylation site {Y481}

Database Correlations

OMIM 107450 UniProt P17181 Entrez Gene 3454 Kegg hsa:3454