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Idursulfase (iduronate-2-sulfatase)

Indications: - Hunter syndrome (mucopolysaccharidosis 2) [2] Mechanism of action: - enzyme replacement - required for the lysosomal degradation of heparan sulfate & dermatan sulfate - hydrolysis of the 2-sulfate groups of L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate & heparin

General

iduronate-2-sulfatase (IDS, alpha-L-iduronate sulfate sulfatase) metabolic agent (metabolic modifier)

References

  1. UniProt :accession P22304
  2. Prescriber's Letter 14(2): 2007 New drugs approved by the FDA in 2006 Detail-Document#: 230213 (subscription needed) http://www.prescribersletter.com
  3. GeneReviews http://www.genetests.org/query?gene=IDS