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ichthyin (ICHN, NIPAL4)
Function:
- receptor for ligands (trioxilins A3 & B3) from the hepoxilin pathway (putative)
Structure: belongs to the NIPA family
Compartment: membrane
Expression:
- highly expressed in brain, lung, stomach, skin & leukocytes, & in all other tissues tested except liver, thyroid & fetal brain
Pathology:
- defects in ICHN are the cause of an autosomal recessive congenital ichthyosis
General
receptor
transmembrane 9 protein
Properties
SIZE: MW = 44 kD
entity length = 404 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {56-76}
transmembrane domain {103-123}
transmembrane domain {125-145}
transmembrane domain {154-174}
transmembrane domain {196-216}
transmembrane domain {224-244}
transmembrane domain {262-282}
transmembrane domain {294-314}
transmembrane domain {325-345}
Database Correlations
UniProt Q0D2K0
Pfam PF05653
References
- UniProt :accession Q0D2K0
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ICHTHYIN