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ibudilast
Indications:
- methamphetamine withdrawal
- may improve vigilance & attention
- may diminish brain volume loss in patients with progressive multiple sclerosis [2]
- approved in Japan in 1989 for use in bronchial asthma & post-stroke dizziness [2]
Dosage:
- 20 mg or 50 mg BID
Adverse effects:
- nausea, diarrhea, abdominal pain
- depression (9% vs 3%)
- rash
- fatigue
Mechanism of action:
- allegedly targets neuroinflammation [1]
- inhibitor factor [2]
- macrophage migration inhibitory factor
- phosphodiesterase-4 inhibitor
- phosphodiesterase-10 inhibitor
- toll-like receptor 4 inhibitor
General
heterocyclic compound, 2 rings
ketone
anti-inflammatory agent
Database Correlations
PUBCHEM cid=3671
References
- Birath JB, Briones M, Amaya S et al.
Ibudilast may improve attention during early abstinence from
methamphetamine.
Drug Alcohol Depend 2017 Jun 23; 178:386.
PMID: 2870476
- Fiore K
Anti-Inflammatory Drug May Offer Benefit in Progressive MS -
Ibudilast seems to diminish brain volume loss;
MedPage Today. October 29, 2017
https://www.medpagetoday.com/MeetingCoverage/ECTRIMS/68865
- Fox RJ et al
SPRINT-MS/NN 102 phase II trial of ibudilast in progressive MS:
top-line results.
ECTRIMS-ACTRIMS 2017; Abstract 278.