hypoxia inducible factor 2

Function: - binds to hypoxia response elements (HREs) of target promoters in the absence of oxygen Structure: - subunits HIF2A, ARNT

General

basic helix loop helix (bHLH) family transcription factor hypoxia inducible factor molecular complex

Properties

COMPARTMENT: cell nucleus MOTIF: basic helix-loop-helix MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix SUBUNITS: hypoxia-inducible factor 2 alpha MOTIF: DNA-binding motif SITE: 15-27 helix-loop-helix NAME: helix-loop-helix SITE: 28-68 FOR-BINDING-VIA: helix-loop-helix PAS domain {84-154} PAS domain {230-300} PAC {304-347} serine residue {474-480} (7) NTAD {496-542} CTAD {830-870} MOTIF: Thr phosphorylation site {T840} aryl hydrocarbon receptor nuclear translocator MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S77} DNA-binding motif SITE: 90-102 MOTIF: arginine-rich region {99-102} MOTIF: arginine residue (SEVERAL) helix-loop-helix NAME: helix-loop-helix SITE: 103-143 FOR-BINDING-VIA: helix-loop-helix PAS domain {161-235} PAS domain {349-419} PAC domain {424-467} glutamine-rich region {503-507} MOTIF: glutamine residue (SEVERAL) glutamine-rich region {710-769} MOTIF: glutamine residue (SEVERAL) serine-rich region {738-741} MOTIF: serine residue (SEVERAL)

Components

aryl hydrocarbon receptor nuclear translocator; ARNT protein; class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta (ARNT, BHLHE2) hypoxia-inducible factor 2 alpha; endothelial PAS domain protein 1; EPAS-1; member of PAS protein 2; MOP2; HIF-2 alpha; HIF-1 alpha-like factor (HIF2A,HLF)