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hypoxia inducible factor 1
Function:
- binds to hypoxia response elements (HREs) of target promoters in the absence of oxygen
- loss of PTEN facilitates HIF-1 mediated gene expression
Structure:
- subunits HIF1A, ARNT
General
basic helix loop helix (bHLH) family transcription factor
hypoxia inducible factor
molecular complex
Properties
COMPARTMENT: cell nucleus
MOTIF: basic helix-loop-helix
MOTIF: basic DNA-binding motif
helix-loop-helix
NAME: helix-loop-helix
FOR-BINDING-VIA: helix-loop-helix
FOR-BINDING-OF: DNA motif
FOR-BINDING-VIA: helix-loop-helix
SUBUNITS: hypoxia-inducible factor 1 alpha
MOTIF: DNA-binding motif
SITE: 17-30
PAS domain {85-158}
PAS domain {228-298}
basic helix-loop-helix
MOTIF: basic DNA-binding motif
helix-loop-helix
NAME: helix-loop-helix
FOR-BINDING-VIA: helix-loop-helix
FOR-BINDING-OF: DNA motif
FOR-BINDING-VIA: helix-loop-helix
aryl hydrocarbon receptor nuclear translocator
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S77}
DNA-binding motif
SITE: 90-102
MOTIF: arginine-rich region {99-102}
MOTIF: arginine residue (SEVERAL)
helix-loop-helix
NAME: helix-loop-helix
SITE: 103-143
FOR-BINDING-VIA: helix-loop-helix
PAS domain {161-235}
PAS domain {349-419}
PAC domain {424-467}
glutamine-rich region {503-507}
MOTIF: glutamine residue (SEVERAL)
glutamine-rich region {710-769}
MOTIF: glutamine residue (SEVERAL)
serine-rich region {738-741}
MOTIF: serine residue (SEVERAL)
References
- Genes Dev 14:391-6, 2000
Components
aryl hydrocarbon receptor nuclear translocator; ARNT protein; class E basic helix-loop-helix protein 2; bHLHe2; Dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta (ARNT, BHLHE2)
hypoxia-inducible factor 1 alpha; ARNT interacting protein; member of PAS protein 1 (HIF1A, MOP1)
Databases & Figures
OMIM 606615
HIF-1 pathway