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hypoxia induced genes
Genes induced by hypoxia regulate various processes including:
1) oxygen transport & iron metabolism
- ceruloplasmin
- erythropoietin
- ferritin light chain
- heme oxygenase 1
- transferrin/transferrin receptor
2) angiogenesis
- adrenomedullin
- angiopoietin 2
- cyclooxygenase 2
- endothelin 1 & endothelin 2
- fibroblast growth factor 3
- hepatocyte growth factor
- histone deacetylase
- monocyte chemotactic protein 1
- nitric oxide synthase
- osteopontin
- placental growth factor
- tie 2 (angiopoietin receptor)
- transforming growth factor alpha
- transforming growth factor beta (1,2,3)
- vascular endothelial growth factor (VEGF) A
- VEGF receptor 1
3) transcription factors
- annexin V
- bcl2-interacting killer (BIK)
- cyclin G2
- differentiated embryo chondrocyte expressed gene 1 (DEC1)
- fos
- jun
- heat shock factor
- hypoxia inducible factor (HIF) -1 alpha, -2 alpha
- insulin like growth factor binding protein 1,2,3
- p27kip1
- lipocortin
- NF kappa B
- NIX (BCL2/adenovirus E1B 19-kD protein-interacting protein 3-like)
- transgelin
- transglutaminase 2
- p21WAF1
4) growth factors/cytokines
- IGF 2
- interleukin 6/8
- intestinal trefoil factor
- macrophage inhibitory factor
- platelet derived growth factor
- staniocalcin
5) glycolysis/glucose uptake
- aldolase A
- enolase 1
- glucose transporter-1/3
- glyceraldehyde-3-phosphate dehydrogenase
- hexokinase-1/2
- lactate dehydrogenase A
- phosphofructokinase C
- phosphofructokinase L
- phosphoglycerate kinase 1
- pyruvate kinase M
6) stress response
- thioredoxin
- 150 kDa oxygen-regulated protein
- GADD153 (growth arrest and DNA damage inducible-153)
- DNA-(apurinic or apyrimidinic site) lyase
7) neurotransmitter production
- tyrosine hydroxylase
- alpha adrenergic receptor
8) metabolism
- acetoacetyl CoA thiolase
- adenylate kinase 3
9) cell adhesion
- CD99
- neural cell adhesion molecule L1
- integrin alpha
10) extracellular matrix
- collagen 5 alpha-1
- matrixin 13
- proline-4-hydroxylase
11) coagulation
- tissue factor
- plasminogen activator inhibitor 1
- urokinase receptor
12) cytoskeleton
- vimentin
General
gene
References
- Harris AL.
Hypoxia-a key regulatory factor in tumour growth.
Nat Rev Cancer. 2002 Jan;2(1):38-47. Review.
PMID: 11902584