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orexin receptor type 2; Ox2r; hypocretin receptor type 2 (HCRTR2)
Function:
- nonselective, high-affinity receptor for both orexin-A & orexin-B neuropeptides
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane, transmembrane 7 protein
Expression:
- upregulated by Sirt1 in dorsomedial hypothalamus & lateral hypothalamus
General
glycoprotein
hypocretin receptor; orexin receptor (Hcrtr)
Properties
SIZE: entity length = 444 aa
MW = 51 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-54}
MOTIF: N-glycosylation site {N14}
N-glycosylation site {N22}
transmembrane domain {55-75}
cytoplasmic loop {76-88}
transmembrane domain {89-110}
exoplasmic loop {111-127}
transmembrane domain {128-150}
cytoplasmic loop {151-172}
transmembrane domain {173-193}
exoplasmic loop {194-224}
MOTIF: N-glycosylation site {N202}
transmembrane domain {225-247}
cytoplasmic loop {248-304}
transmembrane domain {305-327}
exoplasmic loop {328-342}
transmembrane domain {343-366}
cytoplasmic domain {367-444}
Database Correlations
OMIM 602393
UniProt O43614
PFAM correlations
Entrez Gene 3062
Kegg hsa:3062
References
UniProt :accession O43614