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orexin receptor type 1; Ox1r; hypocretin receptor type 1 (HCRTR1)
Function:
- moderately selective excitatory receptor for orexin-A &, with a lower affinity, for orexin-B neuropeptide
- seems to be exclusively coupled to the Gq proteins that activate phospholipase C mediated signaling
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Related
hypocretin; orexin (HCRT, OX, PPORX, PPOX)
General
glycoprotein
hypocretin receptor; orexin receptor (Hcrtr)
phosphoprotein
Properties
SIZE: entity length = 425 aa
MW = 48 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-46}
MOTIF: Tyr phosphorylation site {Y27}
transmembrane domain {47-67}
cytoplasmic loop {68-80}
transmembrane domain {81-102}
exoplasmic loop {103-119}
transmembrane domain {120-142}
cytoplasmic loop {143-164}
transmembrane domain {165-185}
exoplasmic loop {186-216}
MOTIF: N-glycosylation site {N194}
transmembrane domain {217-239}
cytoplasmic loop {240-298}
transmembrane domain {299-321}
exoplasmic loop {322-336}
transmembrane domain {337-360}
cytoplasmic domain {361-425}
Database Correlations
OMIM 602392
UniProt O43613
Pfam PF00001
Entrez Gene 3061
Kegg hsa:3061
References
UniProt :accession O43613