Contents

Search

hypertension clinical trials

Clinical trials: 1) Swedish Trial in Old Patients (STOP) 2) ALLHAT study (thiazide superior to Ca+2 channel blocker or ACE inhibitor) 3) Australian enalapril hypertension study 4) ASCOT LLA trial 5) Women's Health Initiative: Antihypertensives and Cardiovascular Death 6) Perindopril pROtection aGainst REcurrent Stroke Study (PROGRESS) 7) African American Study of Kidney Disease & Hypertension (AASK) 8) Systolic Hypertension in Elderly Program trial (SHEP) 9) Systolic Hypertension in Europe trial 10) Captopril Prevention Project 11) VALUE trial 12) AMAZE trial 13) Nordic diltiazem trial (NORDIL) Observational studies: Women's Health Initiative-Antihypertensives [1] - 30,129 women with hypertension age 50-79 - mean follow-up 5.9 years - Outcome measures: - acute coronary syndrome - stroke - cardiovascular death - conclusions - Ca+2 channel blocker inferior to diuretic, beta blocker, or ACE inhibitor (alone or in combination) - monotherapy with diuretics equal to or superior to other monotherapy - monotherapy with diuretic superior to Ca+2 channel blocker - no comparison data for monotherapy of diuretic vs ACE inhibitor or beta blocker Reviews/meta-analyses: 1) Cochrane Database Syst Rev 2006 [3] - no convincing evidence that lowering blood pressure prevents the development of dementia or cognitive impairment in hypertensive elderly with no apparent prior cerebrovascular disease Pilot studies - 37 primary-care patients >= 70 year of age with systolic BP of > 150 mm Hg [4] - target BP < 130/80 mm Hg (intensive) vs < 140/85 mm Hg (control) - BP reduction 26/17 mm Hg in intesive group vs 15/5 mm Hg in control group - cerebral blood flow in intensive group > than in control group

Specific

ACCOMPLISH trial (Avoiding cardiovascular events through combination therapy in patients living with systolic hypertension) African American Study of Kidney Disease & Hypertension (AASK) AMAZE trial Antihypertensive & Lipid-Lowering Treatment to Prevent Heart Attack (ALLHAT) study ASCOT BPLA trial (atenolol vs amlodipine) Australian enalapril hypertension study Captopril Prevention Project (CAPPP) Cooperate clinical trial hypertension in the very elderly trial (HYVET) International Verapamil SR-Trandolapril Study (INVEST trial) Nordic diltaizem trial (NORDIC) Perindopril pROtection aGainst REcurrent Stroke Study (PROGRESS) Sprint study Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial Swedish Trial in Old Patients (STOP) Systolic Hypertension in Elderly Program (SHEP) trial Systolic Hypertension in Europe (Syst-Eur) trial VALUE trial Women's Health Initiative: Antihypertensives and Cardiovascular Death

General

clinical trial

References

  1. Journal Watch 25(2):15, 2005 Wassertheil-Smoller S, Psaty B, Greenland P, Oberman A, Kotchen T, Mouton C, Black H, Aragaki A, Trevisan M. Association between cardiovascular outcomes and antihypertensive drug treatment in older women. JAMA. 2004 Dec 15;292(23):2849-59. PMID: 15598916
  2. Psaty BM et al, Meta-analysis of health outcomes of chlorthalidone-based vs non chlorthalidone-based low-dose diuretic therapies. JAMA 2004; 292:43 PMID: 15238589
  3. McGuinness B, Todd S, Passmore P, Bullock R. The effects of blood pressure lowering on development of cognitive impairment and dementia in patients without apparent prior cerebrovascular disease. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD004034. Review. PMID: 16625595
  4. Tryambake D et al. Intensive blood pressure lowering increases cerebral blood flow in older subjects with hypertension. Hypertension 2013 Jun; 61:1309 PMID: 23529166 http://hyper.ahajournals.org/content/61/6/1309