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K+/Na+ hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3 KIAA1535)
Function:
- putative hyperpolarization-activated ion channel
- exhibits weak selectivity for K+ over Na+
- the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits
Structure:
- the segment S4 is probably the voltage-sensor; it is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel HCN family
- contains 1 cyclic nucleotide-binding domain
Compartment: membrane
General
hyperpolarization-activated cyclic nucleotide gated K+ channel
glycoprotein
phosphoprotein
transmembrane 6 protein
Properties
SIZE: entity length = 774 aa
MW = 86 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-97}
MOTIF: Involved in subunit assembly {46-91}
transmembrane domain {98-118}
exoplasmic loop {119-124}
transmembrane domain {125-145}
cytoplasmic loop {146-171}
transmembrane domain {172-192}
exoplasmic loop {193-201}
transmembrane domain {202-222}
cytoplasmic loop {223-253}
transmembrane domain {254-274}
exoplasmic loop {275-329}
MOTIF: N-glycosylation site {N291}
H5 (K+) pore-forming region {298-319}
transmembrane domain {330-350}
cytoplasmic domain {351-774}
MOTIF: cAMP-binding site
SITE: 428-545
Ser phosphorylation site {S634}
proline-rich region
SITE: 696-765
MOTIF: proline residue (SEVERAL)
ION-PERMEABILITY: K+
Database Correlations
OMIM 609973
UniProt Q9P1Z3
PFAM correlations
Entrez Gene 57657
Kegg hsa:57657
References
UniProt :accession Q9P1Z3