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hypermethylated in cancer 2 protein; Hic-2; Hic-3; HIC1-related gene on chromosome 22 protein; zinc finger & BTB domain-containing protein 30 (HIC2, HIC3, ZBTB30, HRG22, KIAA1020)
Function:
- transcriptional repressor
- interacts with CtBP
- interacts with HIC1
Structure:
- self-associates
- belongs to the krueppel C2H2-type Zn+2-finger protein family, Hic subfamily
- contains 1 BTB/POZ domain
- contains 5 C2H2-type Zn+2 fingers
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression: highest levels in cerebellum
Related
HIC2 (hypermethylated in cancer 2) gene (HIC1-related gene on chromosome 22)
General
C2H2 type zinc finger protein
nuclear protein
Properties
SIZE: MW = 66 kD
entity length = 615 aa
COMPARTMENT: cell nucleus
MOTIF: BTB domain {46-109}
MOTIF: Zinc finger
NAME: Zinc finger
EFFECTOR-BOUND: Zn+2
Binding to CtBP. {246-250}
Zn finger C2H2-type
SITE: 442-469
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 505-532
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 533-560
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 561-588
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 589-615
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 607712
UniProt Q96JB3
PFAM correlations
Entrez Gene 23119
Kegg hsa:23119
References
UniProt :accession Q96JB3