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hyperleucinemia; leucinosis
Laboratory:
- increased leucine in serum/plasma
Comparative biology:
- mouse models with hyperleucinemia display hippocampus-selective retromer deficiency
* retromer-dependent trafficking is implicated in the pathogenesis of Alzheimer's disease
- 2 key retromer proteins, VPS35 & VPS26, are deficient in the hippocampal formation of patients with Alzheimer's disease [1]
Related
leucine
General
metabolic disease
References
- Morabito MV, Berman DE, Schneider RT et al
Hyperleucinemia causes hippocampal retromer deficiency linking
diabetes to Alzheimer's disease.
Neurobiol Dis. 2014 May;65:188-92. Epub 2014 Jan 14.
PMID: 24440570 Free PMC Article