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hydroxyacid oxidase 1; glycolate oxidase 1 (HAOX1, GOX)
Function:
1) 2-hydroxyacid oxidase activity
2) most active on the 2-carbon substrate glycolate
3) glycolate pathway, 2nd step
4) also active on 2-hydroxy fatty acids.
(S)-2-hydroxy acid + O2 2-oxo acid + H2O2
Cofactor: FMN
Compartment: peroxisome
Expression: expressed in liver
Related
glycolate
General
flavoprotein
oxidoreductase
Properties
SIZE: MW = 41 kD
entity length = 370 aa
COMPARTMENT: peroxisome
MOTIF: tyrosine residue {Y26}
tyrosine residue {Y132}
histidine residue {H260}
arginine residue {R263}
Database Correlations
OMIM 605023
UniProt Q9UJM8
Pfam PF01070
ENZYME 1.1.3.15
References
UniProt :accession Q9UJM8