hydrolase

cleaves substrate with addition of H₂O at cleavage site. includes esterases, phosphatases, nucleases, peptidases.

Specific

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; HIBYL-CoA-H; hib-coa hydrolase (hibch) 6-phosphogluconolactonase (6PGL, PGLS) AB hydrolase superfamily Abhydrolase domain-containing protein 13 (ABHD13, C13orf6) acid ceramidase; acylsphingosine deacylase; N-acylsphingosine amidohydrolase; AC; 32 kD heart protein; PHP32 [Contains: acid ceramidase subunit alpha; acid ceramidase subunit beta] (ASAH1, ASAH) acyloxyacyl hydrolase (AOAH) adenosylhomocysteinase 2; AdoHcyase 2; DC-expressed AHCY-like molecule; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1, DCAL, XPVKONA) adenosylhomocysteinase 3; S-adenosyl-L-homocysteine hydrolase 3; AdoHcyase 3 (AHCYL2, KIAA0828) allantoicase; allantoate amidinohydrolase (ALLC) amidohydrolase aminohydrolase (deaminase) arginase arylsulfatase-E (ARSE) arylsulfatase-F (ASF, ARSF) ataxin-3-like protein (Machado-Joseph disease protein 1-like, ATXN3L, MJDL) beta-ureidopropionase (beta-alanine synthase, N-carbamoyl-beta-alanine amidohydrolase, BUP-1, UPB1, BUP1) bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; glucosaminyl N-deacetylase/N-sulfotransferase 3; NDST-3; hNDST-3; N-heparan sulfate sulfotransferase 3; N-HSST 3; includes: heparan sulfate N-deacetylase 3; heparan sulfate N-sulfotransferase 3 (NDST3, HSST3, UNQ2544/PRO4998) bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferase 4; NDST-4; N-heparan sulfate sulfotransferase 4; N-HSST 4; includes: heparan sulfate N-deacetylase 4; heparan sulfate N-sulfotransferase 4 (NDST4, HSST4) bifunctional purine biosynthesis protein PURH; phospho-ribosyl-amino-imidazole-carboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase (ATIC, PURH, OK/SW-cl86) biotinidase; biotinase; (BTD) Carboxymethylenebutenolidase homolog (CMBL) CD157; ADP-ribosyl cyclase 2; cyclic ADP-ribose hydrolase 2; bone marrow stromal antigen 1 (BST1) CD38; ADP-ribosyl cyclase 1; cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10 ceramidase complement-activating enzyme cytosolic acyl coenzyme A thioester hydrolase; acyl-CoA thioesterase 7; brain acyl-CoA hydrolase; CTE-IIa; CTE-II; long chain acyl-CoA thioester hydrolase (ACOT7, BACH) D-tyrosyl-tRNA(Tyr) deacylase 1 (HARS2, DTD1, C20orf88) di-N-acetylchitobiase (CTBS, CTB) dihydropyrimidinase; DHP; DHPase; dihydropyrimidine amidohydrolase; hydantoinase (DPYS) dimethylarginine dimethylaminohydrolase 1 (NG,NG-dimethylarginine dimethylaminohydrolase 1, dimethylargininase-1, DDAHI, DDAH-1, DDAH1, DDAH) double-strand break repair protein MRE11A; meiotic recombination 11 homolog A; MRE11 homolog A; meiotic recombination 11 homolog 1; MRE11 homolog 1 (MRE11A, HNGS1, MRE11) endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; ER alpha-1,2-mannosidase; ER mannosidase 1; ERman1; man9GlcNAc2-specific-processing alpha-mannosidase; mannosidase alpha class 1B member 1 (MAN1B1) epoxide hydrolase or epoxide hydratase esterase fatty-acid amide hydrolase 1; anandamide amidohydrolase 1; oleamide hydrolase 1 (FAAH, FAAH1) fatty-acid amide hydrolase 2 (oleamide hydrolase 2, anandamide amidohydrolase 2, amidase domain-containing protein, FAAH2, AMDD) fragile histidine triad protein; AP3A hydrolase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase (FHIT) glucosamine-6-phosphate isomerase 2 (glucosamine-6-phosphate deaminase 2, GlcN6P deaminase 2, GNPDA 2, glucosamine-6- phosphate isomerase SB52, GNPDA2) Glycoprotein endo-alpha-1,2-mannosidase-like protein (MANEAL) glycosidase (glycoside hydrolase) GPI inositol-deacylase (hPGAP1, PGAP1) histidine triad nucleotide-binding protein 2 (HINT-2, HINT-3, HIT-17kD, PKCI-1-related HIT protein, HINT2) Histidine triad nucleotide-binding protein 3 (HINT-3, HINT3) hydrolase PNKD (paroxysmal nonkinesiogenic dyskinesia protein, myofibrillogenesis regulator 1, MR-1, trans-activated by hepatitis C virus core protein 2, PNKD, KIAA1184, MR1, TAHCCP2, FKSG19, UNQ2491/PRO5778) hydroxyacylglutathione hydrolase-like protein (HAGHL) imidazolonepropionase (amidohydrolase domain-containing protein 1, AMDHD1) immature colon carcinoma transcript 1 protein; peptidyl-tRNA hydrolase ICT1, mitochondrial; digestion substraction 1; DS-1 (ICT1, DS1) kynureninase; L-kynurenine hydrolase (KYNU) lariat debranching enzyme (DBR1) Lowe's oculocerebral syndrome protein; inositol polyphosphate 5-phosphatase OCRL-1 (OCRL, INPP5F, OCRL1) lysosomal hydrolase mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; mannosidase alpha class 1A member 2; Processing alpha-1,2-mannosidase IB; alpha-1,2-mannosidase IB (MAN1A2, MAN1B) matrix metalloproteinase-15 (matrixin-15, membrane-type matrix metalloproteinase 2, MTMMP2, MMP15, MT2MMP, SMCP-2) matrix metalloproteinase-16 (matrixin-16, membrane-type matrix metalloproteinase 3, MTMMP3, MMPX2 MMP16) mRNA decapping enzyme MSIN3A histone deacetylase complex MSIN3A-like histone deacetylase complex; msin3A-like corepressor complex N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase, amidohydrolase domain-containing protein 2, AMDHD2) N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; phosphatidylinositol-glycan biosynthesis class L protein; PIG-L (PIGL) N-acetylmuramoyl-L-alanine amidase; peptidoglycan recognition protein long; PGRP-L; peptidoglycan recognition protein 2 (PGLYRP2, PGLYRPL, PGRPL, UNQ3103/PRO10102) nitrilase homolog 1 nucleoside diphosphate-linked moiety X motif; Nudix hydrolase family (NUDT) pegloticase (Krystexxa) peptidase; peptide hydrolase peptidyl-tRNA hydrolase 2, mitochondrial (PTH-2, Bcl-2 inhibitor of transcription 1, PTRH2, BIT1, PTH2, CGI-147) peptidyl-tRNA hydrolase PTRH1 (C9orf115) platelet-activating factor acetylhydrolase 1B (PAF acetylhydrolase 1B, PAFAH1B) polyserase-3; polyserine protease 3; protease serine S1 family member 53 (PRSS53) protein-arginine deiminase type-1 (peptidylarginine deiminase 1, PADI, PDI) rodent uricase; methylenetetrahydrofolate dehydrogenase/cyclohydrolase S-adenosyl homocysteine hydrolase (ADOHCYASE, adenosylhomocysteinase, AHCY, SAHH) Sn1-specific diacylglycerol lipase alpha (DGL-alpha, neural stem cell-derived dendrite regulator, DAGLA, C11orf11, KIAA0659, NSDDR) valacyclovir hydrolase; VACVase; biphenyl hydrolase-like protein; biphenyl hydrolase-related protein; Bph-rp; breast epithelial mucin-associated antigen (MCNAA, BPHL) vascular non-inflammatory molecule 3 (Vanin-3, VNN3) [protein ADP-ribosylarginine] hydrolase (ADP-ribosylarginine hydrolase, ADP-ribose-L-arginine cleaving enzyme, ADPRH) [protein ADP-ribosylarginine] hydrolase-like protein 1 (ADP-ribosylhydrolase 2, ADPRHL1 ARH2)

Properties

MOTIF: active site

References

Stedman's Medical Dictionary, 27th ed. Lippincot, Williams & Wilkins, 2000