hydrocodone/phenylpropanolamine (Hycomine, Codamine)

Indication: symptomatic relief of cough & nasal congestion Contraindications: 1) concurrent administration of MAO inhibitor 2) hypertension 3) hyperthyroidism 4) increased intracranial pressure 2) depressed ventilation Dosage: 1) adults & children > 12 years of age: a) 5-10 mL (5-10 mg hydrocodone) every 4-6 hours PRN b) maximum: 6 doses/24 hours 2) children 6-12 years of age: a) 2.5 mL (2.5 mg hydrocodone) every 4-6 hours PRN b) maximum: 6 doses/24 hours Syrup: hydrocodone bitartrate 5 mg & phenylpropanolamine HCl 25 mg/5 mL (120 mL) Adverse effects: 1) common (> 10%) - lightheadedness, dizziness, sedation, drowsiness, weakness, tiredness, hypotension 2) less common (1-10%) - shortness of breath, troubled breathing, confusion, diminished urination, nausea/vomiting, bradycardia, tachycardia 3) uncommon (< 1%) - hallucinations, hypertension, double vision, dry mouth, anorexia, miosis, biliary or urinary spasm, histamine release, hot & dry skin, impaired GI motility, mydriasis, blurred vision 4) other - rash - blood dyscrasias - nephrotoxicity with chronic use - hepatotoxicity - respiratory depression is dose & tolerance-related - tolerance & dependence - constipation Drug interactions: 1) naloxone is a direct opiate antagonist 2) CNS depressants 3) phenothiazines 4) tricyclic antidepressants (TCA)

General

pharmacologic combination antitussive agent

References

Kaiser Permanente Northern California Regional Drug Formulary, 1998

Components

hydrocodone; dihydrocodeinone (Zohydro ER, Hysingla ER) phenylpropanolamine (PPA)