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hydrochlorothiazide/spironolactone; HCTZ/spironolactone (Aldactazide)
HCTZ/spironolactone 25/25 or 50/50.
Indications:
1) management of mild to moderate hypertension
2) treatment of edema in congestive heart failure & nephrotic syndrome Containdications:
Pregnancy category D
Dosage:
1) 1-2 tabs PO QD
2) maximum: 8 tablets/day
Adverse effects:
- not common (1-10%)
- headache, lethargy, rash, hyperkalemia, gynecomastia, hyperchloremic metabolic acidosis (in patients with hepatic cirrhosis), dehydration, hyponatremia, anorexia, nausea/vomiting, diarrhea
Interactions
drug interactions
General
antihypertensive combination
Database Correlations
PUBCHEM cid=188359
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug
Formulary, 1998
Components
hydrochlorothiazide (HCTZ, HydroDIURIL, Oretic, Esidrix)
spironolactone (Aldactone)