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hyaluronoglucosaminidase; hyaluronidase (HYAL)
Function:
- hydrolysis of hyaluronate
- lowers viscosity of hyaluronate, thus increasing tissue permeability
- random hydrolysis of 1->4-linkages between N-acetyl-beta-D-glucosamine & D-glucuronate residues in hyaluronate
Pharmacology: see Hylenex
Related
hyaluronate; hyaluronic acid; hyaluronan
Specific
hyaluronidase PH-20; hyal-PH20; hyaluronoglucosaminidase PH-20; sperm adhesion molecule 1; sperm surface protein PH-20 (SPAM1 HYAL3 PH20)
hyaluronidase-1; hyal-1; hyaluronoglucosaminidase-1; lung carcinoma protein 1; LuCa-1 (HYAL1, LUCA1)
hyaluronidase-2; hyal-2; hyaluronoglucosaminidase-2; lung carcinoma protein 2; LuCa-2 (HYAL2, LUCA2)
hyaluronidase-3; hyal-3; hyaluronoglucosaminidase-3; lung carcinoma protein 3; LuCa-3 (HYAL3, LUCA3)
hyaluronidase-4 (Hyal-4, Hyaluronoglucosaminidase-4, HYAL4)
Hylenex (Wydase, Amphadase, Vitrase, Hydase, hyaluronidase)
General
glycosidase (glycoside hydrolase)
lyase
Properties
MOTIF: active site
Database Correlations
ENZYME 3.2.1.35
References
- UniProt :accession O43820
- UniProt :accession Q12891
- UniProt :accession Q12794
- Wikipedia, Hyaluronidases
http://en.wikipedia.org/wiki/hyaluronidase