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hyaluronidase-4 (Hyal-4, Hyaluronoglucosaminidase-4, HYAL4)
Function:
- endo-hyaluronidase
- degrades hyaluronan to smaller oligosaccharide fragments
- also has chondroitase activity
- random hydrolysis of 1->4-linkages between N-acetyl-beta-D-glucosamine & D-glucuronate residues in hyaluronate
Structure: belongs to the glycosyl hydrolase 56 family
Compartment: membrane
Expression: detected in placenta & skeletal muscle
General
glycoprotein
hyaluronoglucosaminidase; hyaluronidase (HYAL)
membrane protein
Properties
SIZE: entity length = 481 aa
MW = 54 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-8}
transmembrane domain {9-29}
exoplasmic loop {30-453}
MOTIF: cysteine residue {C59}
MODIFICATION: cysteine residue {C351}
N-glycosylation site {N86}
N-glycosylation site {N115}
glutamate residue {E147}
cysteine residue {C223}
MODIFICATION: cysteine residue {C237}
cysteine residue {C237}
MODIFICATION: cysteine residue {C223}
N-glycosylation site {N343}
cysteine residue {C351}
MODIFICATION: cysteine residue {C59}
cysteine residue {C376}
MODIFICATION: cysteine residue {C387}
cysteine residue {C381}
MODIFICATION: cysteine residue {C435}
cysteine residue {C387}
MODIFICATION: cysteine residue {C376}
cysteine residue {C435}
MODIFICATION: cysteine residue {C381}
cysteine residue {C437}
MODIFICATION: cysteine residue {C446}
cysteine residue {C446}
MODIFICATION: cysteine residue {C437}
transmembrane domain {454-474}
cytoplasmic domain {475-481}
Database Correlations
OMIM 604510
UniProt Q2M3T9
Pfam PF01630
ENZYME 3.2.1.35
References
UniProt :accession Q2M3T9